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Chemicals
Palmitoyl Tripeptide-8 CA NO.147732-56-7
<p><strong>Palmitoyl Tripeptide-8</strong> is a synthetic, lipid-modified peptide engineered for advanced cosmetic and dermatological applications, with a primary focus on <strong>soothing sensitive skin and modulating inflammatory responses</strong>. This biomimetic peptide consists of a tripeptide sequence linked to a palmitic acid chain, enhancing its skin penetration and stability. It is specifically designed to…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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About this product
Product information from the supplier.
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Palmitoyl Tripeptide-8 |
| CAS NO. | 147732-56-7 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₃₈H₇₁N₇O₈ |
| Molecular Weight | 754.02 g/mol |
| Purity (RP-HPLC) | ≥98.0% |
| Solubility | Soluble in ethanol, propylene glycol, butylene glycol, and cosmetic oils; sparingly soluble in water |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Potent anti-inflammatory & skin soothing agent: inhibits NF-κB pathway activation, reduces pro-inflammatory cytokines (IL-1α, IL-6, TNF-α); relieves skin redness/irritation; mild anti-wrinkle effect via collagen promotion; compatible with brightening/anti-aging formulations |
| Storage Conditions | Store at 2-8°C in a cool, dry, dark environment; avoid direct sunlight and extreme temperatures; seal tightly after use to prevent moisture absorption. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Palmitoyl Tripeptide-8 functions through a targeted neurosensory and anti-inflammatory mechanism, inspired by the body's natural neuropeptides.
- Substance P Inhibition: Its primary action is to modulate the activity of Substance P (SP), a key neuropeptide released in the skin in response to stressors (e.g., UV, pollution, irritants). Substance P triggers inflammation, redness, itching, and vasodilation.
- Receptor Modulation: The peptide is believed to interact with or influence the Neurokinin-1 Receptor (NK-1R), the primary receptor for Substance P. This interaction helps dampen the pro-inflammatory signaling cascade initiated by Substance P binding.
- Reduction of Neurogenic Inflammation: By inhibiting this pathway, Palmitoyl Tripeptide-8 effectively reduces neurogenic inflammation—the inflammation caused by nervous system signals. This leads to decreased cytokine release, less vasodilation (redness), and a lower sensation of discomfort or itching.
2.PRODUCT INDICATIONS
This product is specifically indicated for cosmetic science and the formulation of products designed to calm and protect sensitive, reactive skin. Key applications include:
- As a core active in soothing serums, creams, and masks for redness-prone, sensitive, or irritated skin.
- In products targeting rosacea, couperose, and conditions characterized by facial flushing.
- For post-procedure care formulations (after lasers, peels, microneedling) to calm the skin and reduce reactivity.
- In anti-stress and anti-pollution skincare designed to strengthen skin's resilience against environmental aggressors.
- As an ingredient in daily moisturizers and treatments to improve skin comfort and tolerance
3.CLINICAL EFFICACY OF PRODUCT
Palmitoyl Tripeptide-8 is supported by in vitro data demonstrating its inhibitory effect on Substance P activity and clinical studies on sensitive skin populations. Evidence from cosmetic trials shows:
- Significant Reduction in Skin Redness: Objective measurements (via chromametry) show a decrease in erythema and visible redness.
- Improved Skin Comfort: Subjects report a marked reduction in sensations of stinging, burning, itching, and tightness.
- Enhanced Skin Barrier Function: Helps strengthen skin resilience, as measured by a reduction in Trans-Epidermal Water Loss (TEWL).
- High Tolerance: Demonstrates excellent tolerability even on highly reactive and sensitized skin types.
Its efficacy validates its role as a potent and targeted ingredient for managing neurosensory inflammation and improving the quality of life for those with sensitive skin.
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
4.Certificate
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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If you have any product requirements, please send an email to:business@huanqiukeji9.com;whatsapp:852 7084 6510
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Global Technology Co., Ltd.
