Prepro TRH (178-199) CAS NO.122018-92-2

<p>Prepro TRH (178-199) is a synthetic 22-amino acid peptide fragment corresponding to residues 178-199 of the prepro-thyrotropin-releasing hormone precursor, supplied as a high-purity lyophilized powder for neuroendocrine research. This peptide encompasses the mature TRH sequence along with its flanking regions, serving as a critical tool for studying TRH biosynthesis, processing enzymes, and the generation of anti…

SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Prepro TRH (178-199)
CAS NO.	122018-92-2
Appearance	White to off-white lyophilized powder
Molecular Formula	C116H176N28O39S
Molecular Weight	2618.92 g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, phosphate‑buffered saline (PBS), or dilute acetic acid (e.g., 0.1% v/v). It is recommended to first dissolve in a small volume of 0.1% acetic acid or sterile water to prepare a 0.1–1.0 mg/mL stock solution.
Endotoxin	< 1.0 EU/mg
Biological Activity	This peptide corresponds to residues 178‑199 of prepro‑thyrotropin‑releasing hormone (prepro‑TRH), which includes the mature TRH sequence. It is used in studies of TRH biosynthesis, processing, and receptor interaction, as well as in immunological assays for antibody production. Bioactivity can be validated in TRH receptor binding or functional assays.
Storage Conditions	Lyophilized powder: Store desiccated at –20 °C or below, protected from light, for long‑term stability. Reconstituted solution: Aliquot and store at ≤ –20 °C; avoid repeated freeze‑thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The peptide itself functions primarily as a substrate and antigen rather than a direct receptor agonist. It is processed by prohormone convertases to yield mature TRH (pyroGlu-His-Pro-NH₂), which then binds to TRH receptors (TRHR1/2) on pituitary thyrotrophs and neurons, activating Gq/11 signaling to increase intracellular calcium and stimulate TSH and prolactin secretion. In immunological applications, the fragment engages B-cell receptors to elicit antibody responses against TRH-related epitopes, enabling detection and quantification of both precursor and mature forms.

2.PRODUCT INDICATIONS

Prepro TRH (178-199) is indicated for research use in TRH biosynthesis and processing studies, including characterization of prohormone convertase activity, investigation of TRH precursor trafficking, and development of immunoassays for TRH and its precursors. It is suitable for academic and pharmaceutical research focused on hypothalamic-pituitary-thyroid axis regulation, neuroendocrine disorders, and antibody generation for immunohistochemistry or radioimmunoassays.

3.CLINICAL EFFICACY OF PRODUCT

As a research-grade peptide substrate and antigen, Prepro TRH (178-199) has no established clinical efficacy or therapeutic application in humans. Its utility is confined to preclinical studies where it facilitates understanding of TRH biology, validation of diagnostic assays, and support for research into thyroid and neuroendocrine pathologies, without direct patient use or regulatory approval for clinical intervention.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.