[Asp371] Tyrosinase(369-377), human CAS NO.168650-46-2

<p>[Asp371] Tyrosinase(369-377), human is a synthetic peptide fragment corresponding to residues 369-377 of the human tyrosinase enzyme, with an aspartic acid substitution at position 371. This sequence represents a key immunodominant epitope recognized by T-cells, making it a crucial research tool for investigating immune responses in melanoma, autoimmune vitiligo, and immunotherapy development.<br/></p>

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[Asp371] Tyrosinase(369-377), human
CAS NO.	168650-46-2
Appearance	White to off-white lyophilized powder
Molecular Formula	C42H66N10O16S2
Molecular Weight	1031.2 g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, phosphate‑buffered saline (PBS), or dilute aqueous solutions. Recommended to dissolve in sterile water to prepare a 0.1–1.0 mg/mL stock solution.
Endotoxin	< 1.0 EU/mg
Biological Activity	This peptide is a modified epitope derived from human tyrosinase, often used in immunological research (e.g., T‑cell activation studies, epitope mapping, vaccine development) related to melanoma and autoimmune vitiligo. The Asp³⁷¹ substitution may alter MHC‑binding affinity and T‑cell recognition.
Storage Conditions	Lyophilized powder: Store desiccated at –20 °C or below, protected from light, for long‑term stability. Reconstituted solution: Aliquot and store at ≤ –20 °C; avoid repeated freeze‑thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The peptide functions as a T-cell epitope. When processed and presented on MHC class I or II molecules by antigen-presenting cells, it binds to specific T-cell receptors (TCRs) on CD8+ cytotoxic T-cells or CD4+ helper T-cells, triggering T-cell activation, proliferation, and effector functions such as cytokine release and cytotoxic activity, thereby initiating an antigen-specific immune response against cells expressing the tyrosinase antigen.

2.PRODUCT INDICATIONS

This peptide is indicated for research applications in immunology and oncology, including T-cell activation and proliferation assays, epitope mapping, melanoma vaccine research, and studies of autoimmune vitiligo pathogenesis. It is also used in the development and validation of immunotherapies, such as adoptive T-cell transfer and cancer vaccines targeting the tyrosinase antigen.

3.CLINICAL EFFICACY OF PRODUCT

As a research-grade reagent, [Asp371] Tyrosinase(369-377) is not a clinically approved therapeutic. However, peptides derived from this epitope are under investigation in clinical trials for melanoma immunotherapy. Early-phase trials have shown that tyrosinase-targeted vaccines can induce specific T-cell responses and, in some cases, objective clinical responses, supporting the potential of this epitope in cancer immunotherapy, though broader efficacy and approval are pending further clinical validation.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Shipping Methods
Main Method: International Air Freight

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