Melanin Concentrating Hormone, human, mouse, rat MCH, human, mouse, rat

Melanin Concentrating Hormone (MCH) is a cyclic 19-amino acid neuropeptide (human, mouse, rat isoforms available) that is a key regulator of energy homeostasis and appetite. It is primarily produced in the lateral hypothalamus and zona incerta. While named for its role in skin color change in fish, in mammals, MCH is a critical orexigenic (appetite-stimulating) peptide that also …

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Melanin Concentrating Hormone
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C105H160N30O26S4
Molecular Weight	2386.8g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water (≥1 mg/mL); reconstitute with sterile distilled water or buffer.
Endotoxin	< 1.0 EU/mg
Biological Activity	Potent endogenous agonist at melanin-concentrating hormone receptors (MCH-R). IC₅₀ values: 0.3 nM (MCH1R), 1.5 nM (MCH2R); EC₅₀ values: 3.9 nM (MCH1R), 0.1 nM (MCH2R). Increases food intake in vivo and regulates energy homeostasis.
Storage Conditions	-20 ± 5 °C, lyophilized powder; avoid repeated freeze-thaw cycles. Stable for 12 months at -20 °C.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

MCH exerts its effects primarily by binding to and activating two G protein-coupled receptors, MCHR1 and MCHR2 (though rodents lack MCHR2).

Appetite Stimulation (Primary via MCHR1): In the hypothalamus, MCH activates MCHR1, which couples to Gi/o proteins, inhibiting adenylyl cyclase. This signaling promotes feeding behavior, reduces energy expenditure, and increases body weight.
Modulation of Other Neurotransmitter Systems: MCH neurons project widely and modulate the activity of dopamine, norepinephrine, serotonin, and orexin/hypocretin systems. This underlies its roles in mood, anxiety, sleep, and reward.
Stress Response: MCH interacts with the hypothalamic-pituitary-adrenal (HPA) axis, influencing the release of corticotropin-releasing hormone (CRH) and cortisol/corticosterone.

2.PRODUCT INDICATIONS

This product is indicated for a wide range of research in metabolism, neuroscience, and pharmacology. Key applications include:

Obesity & Metabolism Research: Studying the central regulation of appetite, energy balance, and the pathophysiology of obesity in rodent models. MCH is a major target for anti-obesity drug discovery.
Neuropsychiatric Research: Investigating the role of MCH in anxiety, depression, stress responses, and addiction (reward pathways).
Sleep-Wake Regulation: Researching its interactions with the orexin system to modulate REM and NREM sleep.
Receptor Pharmacology: As the endogenous ligand for characterizing MCHR1 and MCHR2 (in human/primates) signaling, and for screening receptor antagonists.

3.CLINICAL EFFICACY OF PRODUCT

While MCH itself is not a therapeutic, the MCH system is a highly validated, major target for pharmaceutical development.

Anti-Obesity Target: Preclinical studies show that MCHR1 antagonists or genetic deletion of MCH/MCHR1 leads to reduced food intake, increased energy expenditure, and resistance to diet-induced obesity. This has made MCHR1 a top target for anti-obesity drugs, with several compounds advancing to clinical trials.
Neuropsychiatric Potential: MCHR1 antagonists are also being investigated for the treatment of anxiety, depression, and addiction, based on strong preclinical evidence.
Validated Biological Pathway: Research using MCH peptide has been essential to map the neural circuits controlling energy balance, establishing it as a cornerstone of modern metabolic neuroscience.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.