Neuromedin U-25 CAS NO.312306-89-1

<p>Neuromedin U-25 is a biologically active 25-amino acid neuropeptide primarily expressed in the gastrointestinal tract and central nervous system. This peptide is a potent endogenous ligand for Neuromedin U receptors (NMUR1 and NMUR2), playing a crucial role in regulating energy homeostasis, feeding behavior, gastrointestinal motility, and stress responses, making it a key research tool in neuroendocrinology and m…

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Neuromedin U-25
CAS NO.	312306-89-1
Appearance	White to off-white lyophilized powder
Molecular Formula	C141H203N41O38
Molecular Weight	3080.44g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, phosphate-buffered saline (PBS), or dilute acetic acid (e.g., 0.1% v/v). It is recommended to first dissolve in a small volume of 0.1% acetic acid or sterile water to prepare a 0.1–1.0 mg/mL stock solution.
Endotoxin	< 1.0 EU/mg (by LAL test, typical for research-grade peptides)
Biological Activity	Potent agonist of the Neuromedin U receptors (NMU1R and NMU2R). Exhibits a range of biological activities including regulation of feeding behavior, energy homeostasis, smooth muscle contraction, and modulation of nociception and stress responses.
Storage Conditions	Lyophilized Powder: Store at -20°C or lower in a dry, dark environment. Reconstituted Solution: Aliquot and store at ≤ -20°C. Avoid repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The peptide exerts its effects by binding to and activating the G protein-coupled NMUR1 and NMUR2 receptors. This primarily triggers the Gq/11 signaling pathway, leading to phospholipase C activation, increased intracellular inositol triphosphate and diacylglycerol, and a subsequent rise in cytosolic calcium. This cascade mediates smooth muscle contraction, modulates neurotransmitter release, and influences hypothalamic pathways that control appetite and energy expenditure.

2.PRODUCT INDICATIONS

Neuromedin U-25 is indicated for research applications in neuroscience, endocrinology, and gastroenterology, including studies of appetite regulation and obesity, gastrointestinal motility disorders, stress and anxiety responses, and circadian rhythm modulation. It is used in both in vitro receptor binding and functional assays (e.g., calcium flux) and in vivo models to investigate its physiological roles and therapeutic potential.

3.CLINICAL EFFICACY OF PRODUCT

Neuromedin U-25 is a research-grade peptide and is not an approved therapeutic. Preclinical studies have demonstrated its anorexigenic (appetite-suppressing) effects and ability to increase energy expenditure, positioning the Neuromedin U system as a potential target for anti-obesity drugs. However, its clinical efficacy in humans remains unproven, and no Neuromedin U-based therapies have reached the market, though it continues to be an active area of investigative research.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Shipping Methods
Main Method: International Air Freight

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