Sarafotoxin 6c CAS NO.121695-87-2

<p>Sarafotoxin 6c (S6c) is a highly selective endothelin B (ETB) receptor agonist derived from snake venom, widely used as a standard tool in pharmacological research to study ETB receptor function and vascular physiology . It is characterized by its potent vasoconstrictive effects, which are observed in both endothelium-intact and endothelium-denuded vessels, making it a valuable reagent for investigating receptor-…

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Sarafotoxin 6c
CAS NO.	121695-87-2
Appearance	White to off-white lyophilized powder
Molecular Formula	C103H147N27O37S5
Molecular Weight	2515.g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, PBS, or dilute acetic acid. It is recommended to dissolve in sterile water or buffer to prepare stock solutions for biological assays.
Endotoxin	< 1.0 EU/mg (Typical for research-grade peptides)
Biological Activity	Sarafotoxin 6c is a potent vasoconstrictor and bronchoconstrictor. It acts as a selective agonist for the endothelin B (ET_B) receptor, making it a valuable tool for studying endothelin receptor pharmacology and vascular physiology.
Storage Conditions	Store at -20°C or lower. For long-term storage, keep desiccated at -20°C. Upon reconstitution, aliquot and store at -20°C to avoid repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Sarafotoxin 6c exerts its effects by selectively binding to and activating the endothelin B (ETB) receptor, triggering downstream signaling pathways that lead to vasoconstriction . This mechanism is independent of endothelial integrity, as it induces contraction in both intact and denuded vascular preparations, highlighting its direct action on smooth muscle cells.

2.PRODUCT INDICATIONS

This product is indicated for use in research settings to explore ETB receptor pharmacology, including studies on vascular tone regulation, receptor subtype specificity, and the development of experimental models for cardiovascular diseases. It serves as a critical tool for validating ETB receptor function and for screening potential antagonists or modulators of the endothelin system.

3.CLINICAL EFFICACY OF PRODUCT

Sarafotoxin 6c is intended for research purposes only and is not approved for diagnostic or therapeutic use in humans. Its clinical relevance is confined to its utility as a biochemical reagent in preclinical studies investigating vascular physiology and receptor pharmacology.

4.DELIVERY & SHIPPING

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Main Method: International Air Freight

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