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Chemicals
α-Conotoxin IMI CAS NO.156467-85-5
<p><strong>α-Conotoxin IMI</strong> (CAS NO. 156467-85-5) is a synthetic peptide toxin originally isolated from the venom of the marine cone snail, <em>Conus imperialis</em>. It is a 12-amino acid peptide with two disulfide bonds, forming a specific three-dimensional structure. It is a potent and <strong>selective antagonist of the α3β2 subtype of neuronal nicotinic acetylcholine receptors (nAChRs)</strong>. It is a…
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | α-Conotoxin IMI |
| CAS NO. | 156467-85-5 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₆₀H₈₁N₁₉O₁₆S₄ |
| Molecular Weight | 492.68 g/mol |
| Purity (RP-HPLC) | ≥ 98.5% |
| Solubility | Freely soluble in deionized water (≥ 5 mg/mL) and 0.01 M phosphate-buffered saline (PBS, pH 7.4); soluble in dilute acetic acid; insoluble in methanol, ethanol and chloroform. |
| Endotoxin | ≤ 0.5 EU/mg (Typical for research-grade peptides) |
| Biological Activity | Selective antagonist of neuronal nicotinic acetylcholine receptors (nAChRs), with high affinity for α3β2 and α7 subtypes (IC₅₀: 0.12 μM for α3β2, 0.35 μM for α7); inhibits acetylcholine-induced currents in heterologous expression systems and native neuronal preparations. |
| Storage Conditions | Long-term storage: -80°C in a vacuum-sealed vial, protected from light and moisture. Short-term storage: -20°C for up to 6 months. After reconstitution with sterile water, store at 4°C for ≤ 3 days; aliquot and freeze at -80°C for extended use. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
- Selective Blockade of α3β2 nAChRs: It binds with high affinity and selectivity to the α3β2 subtype of neuronal nicotinic receptors, preventing the binding of acetylcholine and the opening of the receptor's ion channel. It has much lower affinity for other major subtypes like α4β2 or α7.
- Inhibition of Cholinergic Signaling: By blocking these receptors, it inhibits excitatory neurotransmission in specific neuronal pathways where α3β2 receptors are expressed, such as in the autonomic ganglia, certain brain regions, and sensory pathways.
- Modulation of Neurotransmitter Release: Blocking presynaptic α3β2 receptors can modulate the release of other neurotransmitters, including dopamine, norepinephrine, and GABA, influencing circuit activity.
- Neuroscience Research: Studying the specific physiological roles of the α3β2 nicotinic receptor subtype in the central and peripheral nervous systems, and differentiating its functions from other subtypes (e.g., α4β2, α7).
- Pain Research: Investigating the role of α3β2 receptors in nociception (pain perception) and the potential of subtype-specific antagonists as novel, non-opioid analgesics.
- Addiction & Reward Research: Exploring the contribution of α3β2 receptors to the rewarding effects of nicotine and other drugs of abuse, and their role in addiction pathways.
- Target Validation for Pain: Research using α-Conotoxin IMI has been instrumental in demonstrating that blocking α3β2 receptors produces potent analgesia in animal models, without the side effects associated with broader nAChR blockade. This has validated α3β2 as a target for developing non-addictive, non-opioid pain medications.
- Differentiation of Receptor Subtype Functions: Its high selectivity has allowed scientists to definitively attribute specific physiological functions (e.g., in autonomic control, sensory processing) to the α3β2 subtype, separating them from the functions of the more abundant α4β2 and α7 subtypes.
2.PRODUCT INDICATIONS
3.CLINICAL EFFICACY OF PRODUCT
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
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Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Main Method: International Air Freight
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