C-Peptide (57-87), human CAS NO.33017-11-7

<p><strong>C-Peptide (57-87), Human</strong> (CAS NO. 33017-11-7) is a synthetic 31-amino acid peptide corresponding to the human proinsulin C-peptide fragment. It is a crucial biomarker for assessing endogenous insulin secretion and β-cell function. Beyond its diagnostic role, C-peptide is now recognized as a biologically active peptide with therapeutic potential, particularly in mitigating diabetic complications s…

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	C-Peptide (57-87), human
CAS NO.	33017-11-7
Appearance	White to off-white lyophilized powder
Molecular Formula	C₁₂₉H₂₁₁N₃₅O₄₈
Molecular Weight	3020.3 g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in 1% acetic acid at 1 mg/mL; also soluble in aqueous buffers (e.g., PBS) after reconstitution
Endotoxin	< 1.0 EU/mg (Typical for research-grade peptides)
Biological Activity	Exhibits biological activity including modulation of cellular signaling pathways, improvement of Na+/K+-ATPase activity, and potential roles in renal and neural function in diabetes models.
Storage Conditions	-20°C (or -80°C for long-term storage); lyophilized powder stable for 12 months at -20°C; reconstituted solution should be aliquoted and stored at -20°C to avoid repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Receptor Binding and Signaling: C-Peptide binds to a G-protein coupled receptor (GPCR) on the cell surface, leading to the activation of intracellular signaling cascades, including Ca2+ and MAPK pathways.
Enzyme Activation: It stimulates the activity of Na+,K+-ATPase and endothelial nitric oxide synthase (eNOS), which are critical for maintaining vascular tone and cellular ion homeostasis.
Anti-inflammatory and Anti-apoptotic Effects: C-Peptide reduces inflammation and oxidative stress, protecting cells from damage associated with hyperglycemia.

2.PRODUCT INDICATIONS

Diagnostic Marker: Used to differentiate between Type 1 and Type 2 diabetes, assess residual β-cell function, and evaluate hypoglycemia (e.g., insulinoma vs. exogenous insulin administration).
Research Tool: Essential for studying the physiological roles of C-peptide in diabetes complications, vascular biology, and renal function.
Therapeutic Development: Investigated as a potential adjunct therapy to insulin for preventing or reversing diabetic neuropathy and nephropathy.

3.CLINICAL EFFICACY OF PRODUCT

Neuropathy Improvement: C-peptide replacement therapy has shown efficacy in improving sensory nerve function and reducing symptoms of diabetic peripheral neuropathy (DPN) in Type 1 diabetes patients.
Renal Protection: It helps preserve renal function by reducing albuminuria and improving glomerular filtration rate (GFR) in diabetic nephropathy.
Metabolic Stability: The presence of endogenous C-peptide is associated with better glycemic control, reduced insulin requirements, and a lower risk of severe hypoglycemia.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.