C-Reactive Protein (CRP) (77-82) CAS NO.130349-01-8

C-Reactive Protein (CRP) (77-82) (CAS NO.130349-01-8) is a synthetic 6-amino acid peptide fragment derived from the human C-Reactive Protein sequence. With the amino acid sequence Val-Gly-Gly-Ser-Glu-Ile (VGGSEI), this fragment is known for its specific role in modulating immune cell function. It serves as a critical research tool for studying inflammation, neutrophil activity, a…

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	C-Peptide (57-87), human
CAS NO.	33017-11-7
Appearance	White to off-white lyophilized powder
Molecular Formula	C₁₂₉H₂₁₁N₃₅O₄₈
Molecular Weight	3020.3 g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in 1% acetic acid at 1 mg/mL; also soluble in aqueous buffers (e.g., PBS) after reconstitution.
Endotoxin	< 1.0 EU/mg (Typical for research-grade peptides)
Biological Activity	Exhibits biological activity including modulation of cellular signaling pathways, improvement of Na+/K+-ATPase activity, and potential roles in renal and neural function in diabetes models.
Storage Conditions	-20°C (or -80°C for long-term storage); lyophilized powder stable for 12 months at -20°C; reconstituted solution should be aliquoted and stored at -20°C to avoid repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The peptide operates by inhibiting the glycolytic enzyme enolase within human neutrophils. This non-competitive inhibition (Ki ≈ 27 µM) disrupts the cell's energy metabolism by depleting intracellular ATP levels. Consequently, this leads to a significant reduction in superoxide generation (up to 34% inhibition), effectively dampening the oxidative burst and inflammatory response of neutrophils. Unlike other peptides, it does not affect arachidonic acid release or transmembrane potential, indicating a highly specific mechanism targeting cellular energy pathways

2.PRODUCT INDICATIONS

This product is indicated for advanced in vitro research applications, specifically in the fields of inflammation and immunology. It is primarily used to:

Study Neutrophil Function: Investigate the mechanisms of neutrophil-mediated inflammation and oxidative stress.
Cardiovascular Research: Explore the role of CRP fragments in atherogenesis and cardiovascular risk.
Drug Discovery: Serve as a lead compound or tool for screening anti-inflammatory agents targeting neutrophil metabolism

3.CLINICAL EFFICACY OF PRODUCT

While the full-length C-Reactive Protein is a well-established clinical biomarker for inflammation and cardiovascular risk assessment, the CRP (77-82) fragment is primarily a research reagent. Its clinical utility is demonstrated through its efficacy in experimental models where it effectively inhibits neutrophil function and reduces inflammation. Research shows that this peptide can significantly suppress neutrophil influx and protein leakage in models of lung injury, highlighting its potential as a template for developing novel anti-inflammatory therapeutics

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.