CREBtide CAS NO. 149155-45-3

<p><strong>CREBtide</strong> (CAS NO. 149155-45-3) is a synthetic 13-amino acid peptide (KRREILSRRPSYR) derived from the phosphorylation sequence of delta-CREB, a spliced variant of the cAMP response element binding protein. With a molecular weight of 1716.99 g/mol, it serves as a highly specific and efficient substrate for cAMP-dependent protein kinase (PKA). It is widely used in biochemical assays to measure PKA a…

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	CREBtide
CAS NO.	149155-45-3
Appearance	White to off-white lyophilized powder
Molecular Formula	C73H127N29O18
Molecular Weight	1699.01 g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water (≥1 mg/mL); also soluble in aqueous buffers .
Endotoxin	<0.1 EU/μg (Typical for research-grade peptides)
Biological Activity	Synthetic peptide substrate for PKA (cAMP-dependent protein kinase) and PKC; based on the phosphorylation motif of δ‑CREB (cAMP response element‑binding protein).
Storage Conditions	Lyophilized powder: −20°C (stable for ≥12 months); reconstituted solution: aliquot and store at −20°C, avoid repeated freeze‑thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

CREBtide functions as a competitive substrate for protein kinases. It contains a specific serine residue that is phosphorylated by PKA. The peptide mimics the natural phosphorylation site of CREB, allowing researchers to quantify kinase activity by measuring the incorporation of phosphate groups into the peptide. Its mechanism involves binding to the active site of PKA, where it undergoes phosphorylation at a much higher rate and with greater affinity (lower Km) compared to other common substrates like Kemptide.

2.PRODUCT INDICATIONS

Kinase Activity Assays: Used as a high-affinity substrate to measure the activity of PKA in cell lysates or purified enzyme preparations.
Signal Transduction Studies: Employed to investigate the cAMP/PKA signaling pathway and its role in gene expression regulation.
Drug Screening: Utilized in high-throughput screening assays to identify inhibitors or activators of PKA

3.CLINICAL EFFICACY OF PRODUCT

As a research reagent, CREBtide is not used directly in clinical therapy. However, its utility lies in its role as a diagnostic and research tool. By providing a sensitive and specific means to measure PKA activity, it contributes to the understanding of diseases where PKA signaling is dysregulated, such as certain cancers, metabolic disorders, and neurological conditions. Its high specificity (cAK/cGK) makes it a valuable tool for validating the efficacy of experimental drugs targeting the PKA pathway in preclinical research

4.DELIVERY & SHIPPING

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Shipping Methods
Main Method: International Air Freight

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