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Chemicals
D-gamma-Tocotrienol CAS NO.14101-61-2
<p><strong>D-gamma-Tocotrienol</strong> (CAS NO. 14101-61-2) is a high-purity, natural isomer of the vitamin E family, distinct from the more common tocopherols due to its unsaturated isoprenoid side chain. Among the four tocotrienols, gamma-tocotrienol is recognized for exhibiting the <strong>most potent anti-cancer activity</strong>, along with exceptional <strong>anti-inflammatory, neuroprotective, and cholestero…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | D-gamma-Tocotrienol |
| CAS NO. | 14101-61-2 |
| Appearance | Pale yellow to yellow viscous oily liquid or crystalline solid |
| Molecular Formula | C₂₈H₄₂O₂ |
| Molecular Weight | 410.63 g/mol |
| Purity (RP-HPLC) | ≥98.0% |
| Solubility | Soluble in DMSO (~10 mg/mL), DMF, chloroform, and ethanol; sparingly soluble in aqueous solutions |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Potent antioxidant; inhibits lipid peroxidation; exhibits anti-inflammatory, neuroprotective, and cholesterol-lowering effects; may support cardiovascular health |
| Storage Conditions | Store at -20°C, protected from light and moisture; avoid repeated freeze-thaw cycles |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
- Superior Antioxidant & Anti-inflammatory Action: Its unsaturated side chain allows for more uniform cellular membrane distribution, providing highly efficient protection against lipid peroxidation. It potently inhibits pro-inflammatory signaling pathways, including NF-κB and STAT3.
- Potent Induction of Apoptosis in Cancer Cells: D-gamma-Tocotrienol is particularly effective at inducing programmed cell death in a wide range of cancer cell lines. Key mechanisms include:
- Endoplasmic Reticulum (ER) Stress Induction: It triggers the unfolded protein response (UPR), leading to apoptosis.
- Inhibition of Oncogenic Pathways: It suppresses the PI3K/Akt/mTOR, NF-κB, and Wnt/β-catenin signaling pathways crucial for cancer cell survival and proliferation.
- Modulation of Cell Cycle and Death Receptors.
- HMG-CoA Reductase Regulation: Like other tocotrienols, it induces the ubiquitination and proteasomal degradation of HMG-CoA reductase, the key enzyme in cholesterol synthesis, thereby lowering serum cholesterol.
2.PRODUCT INDICATIONS
- Oncology Research & Support: Primary ingredient in research formulations for cancer chemoprevention and as an adjuvant in cancer therapy. Key focus for breast, prostate, colon, and pancreatic cancers.
- Cardiovascular Health: Dietary supplements aimed at managing cholesterol levels and preventing atherosclerosis.
- Neuroprotection: Formulations targeting brain health, cognitive function, and protection against neurodegenerative diseases.
- Cosmetic & Skincare: High-efficacy active in anti-aging, reparative, and protective serums/creams due to its deep skin penetration and powerful antioxidant capacity.
- General Wellness & Inflammation Management: Broad-spectrum anti-inflammatory and antioxidant supplements.
3.CLINICAL EFFICACY OF PRODUCT
- Anti-cancer Potential: Preclinical studies consistently show that gamma-tocotrienol is the most potent tocotrienol isomer against cancer, with efficacy in animal models of various cancers. Early-phase human clinical trials for its use in combination therapy are promising.
- Cholesterol Management: Human studies on mixed tocotrienols (rich in gamma and delta) demonstrate significant reductions in total cholesterol, LDL cholesterol, and triglycerides.
- Neuroprotection: Evidence suggests benefits in reducing the progression of white matter lesions and supporting overall brain health.
- Safety Profile: Exhibits an excellent safety profile in studies, with no serious adverse effects reported at efficacious doses.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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If you have any product requirements, please send an email to:business@huanqiukeji9.com;whatsapp:852 7084 6510
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