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Chemicals
Urolithin C CAS NO.165393-06-6
<p><strong>Urolithin C</strong> (CAS NO. 165393-06-6) is a high-purity, gut microbiota-derived metabolite belonging to the <strong>urolithin</strong> family (benzo[c]chromen-6-ones). It is structurally distinct from Urolithins A and B, featuring a different hydroxylation pattern. Like other urolithins, it is formed from the transformation of ellagitannins and is absorbed into circulation. Urolithin C is gaining atte…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Urolithin C |
| CAS NO. | 165393-06-6 |
| Appearance | Off-white to beige powder |
| Molecular Formula | C₁₃H₈O₅ |
| Molecular Weight | 244.20 g/mol |
| Purity (RP-HPLC) | ≥98.0% |
| Solubility | Soluble in DMSO (2–125 mg/mL, sonication recommended); slightly soluble in methanol (with heating); insoluble in water |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Glucose-dependent activator of insulin secretion; L-type Ca²⁺ channel opener; induces apoptosis via mitochondrial pathway; exhibits antioxidant and antiproliferative activity |
| Storage Conditions | Powder: -20°C for 3 years / 4°C for 2 years (inert atmosphere recommended); In solution: -80°C for 6 months / -20°C for 1 month |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Potent Anti-inflammatory Action: It strongly inhibits the production of key pro-inflammatory mediators. Research indicates it is a highly effective suppressor of the NLRP3 inflammasome, a multi-protein complex critical for the production of IL-1β and IL-18, which are drivers of chronic inflammatory diseases. It also inhibits NF-κB signaling.
- Induction of Apoptosis & Cell Cycle Arrest: In cancer cells, Urolithin C can induce apoptosis (programmed cell death) and cause cell cycle arrest, potentially through modulation of mitochondrial pathways and key regulatory proteins.
- Modulation of Cellular Metabolism & Signaling: As a microbially derived polyphenol metabolite, it can interact with various cellular signaling pathways (e.g., MAPK, PI3K/Akt) and influence metabolic processes, though its specific effects on mitophagy are less characterized than Urolithin A.
Antioxidant Activity: It exhibits direct free radical scavenging ability, contributing to the reduction of oxidative stress.
2.PRODUCT INDICATIONS
Inflammation & Immunology Research: As a potent and specific NLRP3 inflammasome inhibitor for studying chronic inflammatory diseases, such as inflammatory bowel disease (IBD), arthritis, metabolic inflammation, and neuroinflammation.
- Oncology Research: Investigating its anti-proliferative and pro-apoptotic effects in various cancer models.
- Gut-Brain Axis & Neurodegeneration Research: For studies on how gut metabolites influence brain health, neuroinflammation, and conditions like Alzheimer's and Parkinson's disease.
- Microbiome & Nutrigenomic Studies: As a specific metabolite to study host-microbiome interactions, inter-individual variability in polyphenol metabolism, and the development of targeted "postbiotic" interventions.
Comparative Urolithin Research: Essential for elucidating the structure-activity relationships (SAR) within the urolithin family to identify the most potent compounds for specific health applications.
3.CLINICAL EFFICACY OF PRODUCT
Urolithin C is a preclinical research compound. Its clinical efficacy in humans has not been established through controlled trials. Its significance is based on:
- Robust Preclinical Evidence: Strong in vitro and emerging in vivo data demonstrate its potent anti-inflammatory activity, particularly via NLRP3 inflammasome inhibition, and promising anti-cancer effects. Studies show it can be as or more potent than other urolithins in certain assays.
- Human Presence & Relevance: Urolithin C, along with other urolithins, is detected in human plasma and urine after consumption of ellagitannin-rich foods, confirming its bioavailability and relevance as a human metabolite.
- Clinical Potential: Its unique mechanism as an NLRP3 inhibitor positions it as a compelling candidate for drug development in NLRP3-driven diseases, an area of intense pharmaceutical interest. The clinical success of Urolithin A in muscle health trials paves the way for investigating other urolithins.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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