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Chemicals
Corydalmine CAS NO.30413-84-4
<p><strong>Corydalmine</strong> (CAS NO. 30413-84-4) is a high-purity, naturally occurring isoquinoline alkaloid belonging to the <strong>tetrahydroprotoberberine</strong> class. It is extracted from traditional medicinal herbs such as <em>Corydalis yanhusuo</em>(Yan Hu Suo). This compound is of significant interest in pharmacological research due to its diverse and potent biological activities, primarily its <stron…
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Corydalmine |
| CAS NO. | 30413-84-4 |
| Appearance | Off-white to light yellow solid powder |
| Molecular Formula | C₂₀H₂₃NO₄ |
| Molecular Weight | 341.40–341.41 g/mol |
| Amino Acid Sequence | β-Ala-His |
| Purity (RP-HPLC) | ≥95% |
| Solubility | Soluble in water (approx 17 mg/mL at 25°C); slightly soluble in ethanol; insoluble in ether and acetone |
| Endotoxin | <0.1 EU/mg |
| Biological Activity | Inhibits spore germination of plant pathogens/saprophytic fungi; acts as an oral analgesic with potent pain-relief effects |
| Storage Conditions | - Powder: Store at -20°C (long-term, 3 years) or 4°C (short-term, 2 years), protected from light and moisture- In solution: Store at -80°C (6 months) or -20°C (1 month) |
| Stock Location | Stock in USA |
| MOQ | 10g |
1.MECHANISM OF ACTION
- Dopamine Receptor Antagonism: It acts as a potent antagonist of dopamine D2 and D3 receptors. This action is central to its observed effects and differentiates it from typical opioid analgesics. By blocking these receptors, it modulates mesolimbic dopamine pathways involved in pain perception, reward, and addiction.
- Anti-inflammatory Action: It inhibits the production of key pro-inflammatory mediators (such as TNF-α, IL-6, IL-1β, PGE2, and NO) by suppressing the activation of the NF-κB and MAPK signaling pathways. It also inhibits microglial activation, which is crucial in neuroinflammation.
- Analgesic (Pain-Relieving) Effects: Its analgesic effect is mediated through multiple non-opioid mechanisms, primarily via dopamine receptor blockade and anti-inflammatory action. It does not act on mu-opioid receptors, suggesting a lower risk of addiction and respiratory depression compared to classical opioids.
- Neuroprotection: It protects neuronal cells from oxidative stress and apoptosis, which is relevant for research in neurodegenerative diseases and stroke.
2.PRODUCT INDICATIONS
- Pain Research & Analgesic Development: As a novel, non-opioid lead compound for the development of new analgesic drugs, especially for chronic inflammatory and neuropathic pain.
- Neuropsychiatric & Addiction Research: For studying the role of dopamine receptors in conditions like drug addiction, schizophrenia, and Parkinson's disease.
- Inflammation & Immunology Research: Investigating natural compounds for the treatment of chronic inflammatory and autoimmune diseases.
- Neurodegeneration Research: Studies on Alzheimer's disease, Parkinson's disease, and other conditions involving neuroinflammation and dopaminergic dysfunction.
Natural Product & Phytochemistry: As a reference standard for the authentication, quantification, and quality control of Corydalisextracts and related herbal medicines.
3.CLINICAL EFFICACY OF PRODUCT
- Preclinical Efficacy: Numerous in vitro and in vivo studies have demonstrated its potent analgesic efficacy in various animal models of pain (inflammatory, neuropathic, cancer-induced) that is comparable to morphine in some models, but without inducing tolerance or rewarding effects. Its anti-inflammatory and neuroprotective effects are also well-validated in animal models.
- Traditional Medicine Validation: Corydalis yanhusuo, the primary plant source, has been used for centuries in Traditional Chinese Medicine (TCM) specifically for pain relief (e.g., abdominal pain, chest pain, dysmenorrhea) and cardiovascular conditions, providing a strong ethnopharmacological basis for its bioactivity.
Clinical Translation Potential: Its unique non-opioid, multi-target mechanism makes it a highly promising candidate for the development of safer, non-addictive analgesics. It addresses a critical unmet medical need. Further pharmacokinetic, toxicological, and human clinical trials are the necessary next steps.
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
4.Certificate
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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