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Chemicals
Acetyl Hexapeptide-49 CAS NO.1459205-54-9
<p><strong>Acetyl Hexapeptide-49</strong> is a high-purity, synthetic, and acetylated hexapeptide engineered for advanced anti-aging skincare. The N-terminal acetylation enhances metabolic stability and skin penetration. This innovative peptide acts as a potent <strong>cell-communicating signal molecule</strong>, designed to mimic natural biological signals that stimulate dermal repair. It specifically targets the <…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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About this product
Product information from the supplier.
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Acetyl Hexapeptide-49 |
| CAS NO. | 1459205-54-9 |
| Appearance | White to off-white lyophilized powder, odorless |
| Molecular Formula | C₅₁H₅₇N₉O₈ |
| Molecular Weight | 923.61 g/mol |
| Purity (RP-HPLC) | ≥98.0% |
| Solubility | Soluble in water (≥1 mg/mL) and DMSO; also soluble in 0.1% TFA/water |
| Endotoxin | <0.1 EU/mg |
| Biological Activity | Inhibits PAR-2 receptor activity (up to 80%), reduces IL-6/IL-8 release (69.6%/71.5%), soothes sensitive skin, restores barrier function, and enhances hydration |
| Storage Conditions | Lyophilized powder: -20°C (long-term, 2 years) / -80°C (extended storage); avoid repeated freeze-thaw cycles; protect from moisture and light |
| Stock Location | Stock in USA |
| MOQ | 10g |
1.MECHANISM OF ACTION
- Receptor-Mediated Fibroblast Activation: Its sequence is designed to interact with specific cell surface receptors on dermal fibroblasts. This binding triggers intracellular signaling cascades, primarily involving pathways like MAPK/ERK, that upregulate gene expression.
- Upregulation of Structural Protein Synthesis: This signaling leads to a significant increase in the production of collagen (Types I, III, IV), elastin, fibronectin, and glycosaminoglycans (GAGs). These are the essential building blocks for skin strength, snap-back, and hydration.
- Reinforcement of the Dermal-Epidermal Junction (DEJ): It promotes the synthesis of DEJ-specific proteins (e.g., collagen XVII, laminin), strengthening the critical anchor between skin layers to improve firmness and resistance to gravity-induced sagging.
- Dermal Remodeling & Thickening: The collective increase in ECM components results in a thicker, denser, and more organized dermis, which visibly translates to plumper, smoother, and more resilient skin.
2.PRODUCT INDICATIONS
- This peptide is specifically formulated for high-efficacy cosmetic products targeting pronounced signs of aging:
- Intensive Anti-Wrinkle & Firming Serums/Creams: For deep wrinkles, loss of contour, and compromised skin elasticity.
- Neck & Décolletage Rejuvenation: Specialized treatments for areas prone to fine lines and laxity.
- Facial Lifting & Contouring Formulations: To improve jawline definition and counteract sagging.
- Premium Skin Renewal Programs: For comprehensive restoration of a more youthful skin architecture.
3.CLINICAL EFFICACY OF PRODUCT
- In Vitro Validation: Demonstrates a dose-dependent stimulation of collagen I synthesis (up to 150% increase) and other ECM proteins in human dermal fibroblast cultures.
- Clinical Instrumental Measurements: Studies show a significant increase in skin firmness (up to 20% improvement via cutometry) and improved elasticity (up to 15% increase) after 28-56 days of use.
- Visual & Imaging Results: 3D skin imaging analysis confirms a reduction in wrinkle volume (up to 25%) and depth. Expert grading shows a visible improvement in overall skin smoothness and tightness.
- Consumer-Perceived Benefits: High participant satisfaction scores for improved skin firmness, reduced appearance of sagging, and a more revitalized look.
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
The efficacy of Acetyl Hexapeptide-49 is validated by robust in vitro data and clinical studies on finished formulations:
4.Certificate
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
Hot Tags: Pentapeptide-25, Anti-aging peptide, Collagen booster, Skin firming, Wrinkle reducer, Cosmetic ingredient, Peptide synthesis, Skincare, CAS 1000313-64-36, Synthetic peptide, Dermal repair, Extracellular matrix, Fibroblast activation, Topical serum, Cosmetic research, High purity peptide, Supplier, Manufacturer, Bulk order, Cosmetic raw materialResearch peptide, Pharmaceutical
If you have any product requirements, please send an email to:business@huanqiukeji9.com;whatsapp:852 7084 6510
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Global Technology Co., Ltd.
