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Chemicals
Gomisin J CAS NO.66280-25-9
<p><strong>Gomisin J</strong> (CAS NO. 66280-25-9) is a high-purity, single-component <strong>dibenzocyclooctadiene lignan</strong> extracted and purified from <em>Schisandra chinensis</em>. It represents one of the key bioactive constituents responsible for the renowned pharmacological effects of this important adaptogenic herb. This compound is characterized by its <strong>unique complex molecular structure</stron…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Gomisin J |
| CAS NO. | 66280-25-9 |
| Appearance | White to off-white crystalline powder; odorless |
| Molecular Formula | C22H28O6 |
| Molecular Weight | 388.45 g/mol |
| Purity (RP-HPLC) | ≥98.0% |
| Solubility | Freely soluble in DMSO, Chloroform, Dichloromethane, Ethyl Acetate, Acetone; slightly soluble in Ethanol; sparingly soluble in Water |
| Endotoxin | <0.1 EU/mg |
| Biological Activity | Anti-Inflammatory: Suppresses NF-κB and COX-2 pathways. Cytoprotective: Protects against cerebral ischemia/reperfusion injury and cardiomyocyte damage. Anticancer: Induces apoptosis and necroptosis in various cancer cell lines |
| Storage Conditions | -20°C Freezer, desiccated, and protected from light. Short term storage at 2–8°C is acceptable. Avoid repeated freeze-thaw cycles. |
| Stock Location | Stock in USA |
| MOQ | 10g |
1.MECHANISM OF ACTION
- Hepatoprotection via Multi-Target Action in Liver Cells: It protects hepatocytes through a combination of mechanisms:
- Anti-inflammatory Action: Potently inhibits the NF-κB and MAPK signaling pathways, reducing the production of TNF-α, IL-6, and other cytokines that drive liver inflammation and injury.
- Anti-apoptosis: Modulates the Bcl-2/Bax ratio and inhibits caspase activation, preventing programmed cell death in liver cells exposed to toxins (e.g., acetaminophen, CCl₄, ethanol).
- Antioxidant & Detoxification Induction: Activates the Nrf2 antioxidant pathway, upregulating protective enzymes like heme oxygenase-1 (HO-1).
- Anti-cancer Activity via Apoptosis Induction & Cell Cycle Arrest: In cancer cells, it triggers intrinsic apoptosis, causes cell cycle arrest (often at G0/G1), and inhibits proliferative/survival signals such as the PI3K/Akt/mTOR and STAT3 pathways.
- Neuroprotection: Demonstrates protective effects in neuronal models, potentially by reducing oxidative stress, excitotoxicity, and apoptosis, relevant for stroke and neurodegenerative disease research.
2.PRODUCT INDICATIONS
- Hepatology & Toxicological Research: As a reference hepatoprotective agent for studying drug-induced liver injury (DILI), alcoholic/non-alcoholic fatty liver disease (NAFLD/NASH), hepatitis, and liver fibrosis.
- Oncology Research: As a cytotoxic and pro-apoptotic lead for investigating chemoprevention and therapy in models of liver cancer, breast cancer, and other malignancies.
- Inflammation & Immunology Research: For developing natural inhibitors of chronic inflammatory and autoimmune conditions.
- Natural Product & TCM Standardization: As the definitive chemical marker for the authentication, quantification, and quality control of Schisandra chinensisraw materials, extracts, and finished herbal products. Its concentration is a direct indicator of potency.
- Neuropharmacology: Preliminary research tool in models of cerebral ischemia and neurodegeneration.
3.CLINICAL EFFICACY OF PRODUCT
- Extensive Preclinical Validation: Robust in vitro and in vivo data confirms its significant efficacy in protecting the liver from various toxins, inhibiting tumor growth, and reducing inflammation in standardized animal models. It is a major contributor to the biological activity of Schisandra extracts.
- Traditional & Modern Clinical Heritage: Schisandra chinensis(standardized by its lignan content, including Gomisin J) has a millennia-long history in TCM for liver health, vitality, and as an adaptogen. Modern clinical trials on Schisandra berry extracts show benefits in improving liver function markers in patients with hepatitis, validating the therapeutic pathway targeted by Gomisin J.
- Pharmacological Benchmark: Its presence and concentration are used globally to standardize Schisandra supplements and extracts, ensuring product efficacy for liver support, stress adaptation, and antioxidant protection.
- Drug Discovery Potential: Its favorable multi-target activity profile makes it a prime candidate for the development of novel hepatoprotective or chemopreventive drugs. Further human clinical trials on the purified compound are warranted.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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