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Scoparone CAS NO.120-08-1
Chemicals

Scoparone CAS NO.120-08-1

<p><strong>Scoparone</strong> (6,7-Dimethoxycoumarin) (CAS NO. 120-08-1) is a high-purity, single-component coumarin derivative. It is a key bioactive constituent of several traditional medicinal herbs, most notably <em>Artemisia scoparia</em>. This compound is celebrated for its <strong>broad and potent pharmacological profile</strong>, with well-documented <strong>vasodilatory, anti-hypertensive, hepatoprotective,…

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TECHNICAL SPECIFICATIONS


Item
Specification
Product Name
Scoparone
CAS NO.
120-08-1
Appearance
White to pale yellow crystalline powder / solid
Molecular Formula
C₁₁H₁₀O₄
Molecular Weight
206.19 g/mol
Purity (RP-HPLC)
≥98%
Solubility
Soluble in DMSO (≥15 mg/mL), ethanol, methanol, chloroform; partially miscible in water; insoluble in petroleum ether
Endotoxin
<0.1 EU/mg
Biological Activity
Exhibits vasorelaxant, anticoagulant, hypolipidemic, antioxidant, and anti-inflammatory effects; acts as a CAR activator
Storage Conditions
Powder: Store at -20°C (long-term, 3 years) or 2-8°C (short-term, 1 year), sealed, dry, and protected from light
Stock solutions: Store at -80°C (1 year) or -20°C (1 month)
Stock Location
Stock in USA
MOQ
10g


1.MECHANISM OF ACTION

  • Vasodilation & Anti-hypertensive Action: It acts as a calcium channel antagonist in vascular smooth muscle cells and stimulates the endothelial nitric oxide synthase (eNOS) pathway, increasing nitric oxide (NO) production. This dual action promotes vasodilation, reduces peripheral resistance, and lowers blood pressure.

  • Potent Anti-inflammatory & Immunomodulation: It suppresses the production of key pro-inflammatory cytokines (TNF-α, IL-6, IL-1β) and mediators (PGE2, NO) by inhibiting the activation of the NF-κB and MAPK (p38, JNK, ERK) inflammatory signaling pathways.

  • Hepatoprotection & Anti-fibrosis: It protects hepatocytes from apoptotic and inflammatory damage. Crucially, it inhibits the activation of hepatic stellate cells (HSCs)—the primary drivers of liver fibrosis—by suppressing the TGF-β1/Smad and PI3K/Akt/mTOR signaling pathways, thereby reducing collagen deposition.

  • Antioxidant Activity: It demonstrates direct free radical scavenging ability, mitigating oxidative stress in tissues.


  • 2.PRODUCT INDICATIONS

  • Cardiovascular & Hypertension Research: As a lead compound for developing novel anti-hypertensive and vasoprotective drugs. Ideal for studying pulmonary arterial hypertension (PAH) and atherosclerosis.

  • Hepatology & Liver Disease Research: For preclinical studies on drug-induced liver injury (DILI), alcoholic/non-alcoholic steatohepatitis (NASH), liver fibrosis, cirrhosis, and cholestasis.

  • Inflammation & Autoimmunity Research: As a tool compound for investigating NF-κB/MAPK pathway inhibitors in conditions like sepsis, arthritis, and inflammatory bowel disease (IBD).

  • Pulmonary Disease Research: Emerging applications in models of lung fibrosis and pulmonary hypertension.

  • Natural Product Standardization: As the definitive analytical reference standard for the quality control and authentication of Artemisia scopariaand related medicinal plant extracts.


    • 3.CLINICAL EFFICACY OF PRODUCT

  • Robust Preclinical Efficacy: Extensive in vitro and in vivo studies across multiple species and disease models have consistently demonstrated its significant efficacy in lowering blood pressure, protecting against liver toxins, reversing fibrosis, and reducing inflammation. Its effects are dose-dependent and mechanistically well-defined.

  • Traditional Medicine Foundation: Its source plant, Artemisia scoparia(Yin Chen Hao), is a cornerstone herb in Traditional Chinese Medicine (TCM) for treating jaundice, liver disorders, and damp-heat conditions, providing centuries of ethnopharmacological validation for Scoparone's activity.

  • Clinical Translation Context: Artemisiaextracts standardized for Scoparone are used in some healthcare systems. Its identification as a major active principle drives the scientific rationale for these applications. It is a prime candidate for pharmaceutical development.

  • Research & Development Value: Its ability to target multiple disease pathways (hypertension, fibrosis, inflammation) with one molecule makes it a highly efficient and promising candidate for multi-indication drug development programs.


      • 4.Certificate

      • GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

      Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.


      We prioritize:

      1.A rigorous quality management system

      2.Batch traceability and stability data

      3.Professional laboratory testing and validation

      4.Compliance with international trade standards


      Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

      5.DELIVERY & SHIPPING

      We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

      Professional and Secure Packaging

      Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

      We can also customize packaging according to customer needs.

      Shipping Methods 

      Main Method: International Air Freight

      We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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      Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

      We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.


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      If you have any product requirements, please send an email to:business@huanqiukeji9.com;whatsapp:852 7084 6510

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