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Chemicals
8-Methoxypsoralen CAS NO.298-81-7
<p>8-Methoxypsoralen (8-MOP, Xanthotoxin), with the CAS registry number 298-81-7, is a naturally occurring linear furocoumarin compound. It is a white to off-white crystalline powder, primarily extracted from plants like <em>Ammi majus</em>and is also synthesized. It is the principal photosensitizing agent used in PUVA (Psoralen + UVA) photochemotherapy. As a critical active pharmaceutical ingredient (API), it is fo…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | 8-Methoxypsoralen |
| CAS NO. | 298-81-7 |
| Appearance | White to off-white crystalline powder |
| Molecular Formula | C₁₂H₈O₄ |
| Molecular Weight | 216.19 g/mol |
| Purity (RP-HPLC) | ≥98% |
| Solubility | Soluble in chloroform, ethanol, DMSO; sparingly soluble in water; insoluble in petroleum ether |
| Endotoxin | <0.1 EU/mg |
| Biological Activity | Phototoxic, photosensitizing agent; used in photochemotherapy for skin disorders (e.g., psoriasis, vitiligo). |
| Storage Conditions | Store in a cool, dry, dark place; sealed container at 2-8°C to avoid light degradation. |
| Stock Location | Stock in USA |
| MOQ | 10g |
1.MECHANISM OF ACTION
- 8-Methoxypsoralen's therapeutic action is light-dependent. Upon systemic or topical administration, it intercalates into DNA. Subsequent exposure to long-wavelength ultraviolet A (UVA, 320-400 nm) radiation induces a photochemical reaction. The activated 8-MOP molecules form covalent mono-adducts and interstrand cross-links with thymine bases in DNA. This inhibits DNA replication and cellular proliferation, which is particularly effective against rapidly dividing cells (e.g., hyperproliferative keratinocytes in psoriasis) and activated T-lymphocytes. It also induces apoptosis and modulates local immune responses in the skin.
2.PRODUCT INDICATIONS
This API is supplied for the development and production of medications specifically indicated for photochemotherapy. Its primary and well-established therapeutic use is in the PUVA treatment of severe skin disorders, including psoriasis (plaque-type, palmoplantar), vitiligo (for repigmentation), and cutaneous T-cell lymphoma (e.g., mycosis fungoides). It is also used in research for extracorporeal photopheresis (ECP). This product is intended strictly for pharmaceutical R&D, quality control, and the manufacture of finished dosage forms under medical supervision.
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
3.CLINICAL EFFICACY OF PRODUCT
8-Methoxypsoralen is a cornerstone of PUVA therapy with a long history of proven clinical efficacy. It is highly effective in clearing psoriatic plaques, with a significant majority of patients achieving complete or near-complete clearance after a course of treatment. In vitiligo, it can induce clinically significant repigmentation, particularly in stable, localized disease. For early-stage cutaneous T-cell lymphoma, PUVA therapy can lead to disease remission. Treatment efficacy is dose- and light-dependent, requiring careful protocols managed by healthcare professionals to balance benefits with known risks of phototoxicity and long-term side effects.
4.Certificate
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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