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Chemicals
ligustroflavone CAS NO.260413-62-5
<p>Ligustroflavone is a high-purity natural flavonoid extracted from <em>Ligustrum lucidum</em>(Glossy Privet), standardized for research and development applications. This bioactive compound is characterized by its multi-target mechanism as a Calcium-Sensing Receptor (CaSR) antagonist, offering significant potential in metabolic and age-related disease research. It is supplied as a stable solid under strict quality…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | ligustroflavone |
| CAS NO. | 260413-62-5 |
| Appearance | White to off-white crystalline powder |
| Molecular Formula | C33H40O18 |
| Molecular Weight | 724.66 g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in DMSO, methanol; slightly soluble in ethanol; insoluble in water |
| Endotoxin | <0.5 EU/mg |
| Biological Activity | CaSR antagonist, anti-necroptotic agent, TGF-β/Smad pathway inhibitor |
| Storage Conditions | Store at -20°C, protected from light and moisture |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Ligustroflavone functions primarily as an allosteric antagonist of the Calcium-Sensing Receptor (CaSR), which modulates extracellular calcium signaling and parathyroid hormone (PTH) secretion to restore calcium homeostasis. Beyond calcium regulation, it inhibits key pathological pathways including the RIPK1/RIPK3/MLKL-mediated necroptosis cascade and the TGF-β/Smad signaling axis, thereby reducing fibrosis and cellular programmed death. Additionally, it activates the GSK3β/NRF2 pathway to alleviate oxidative stress and ferroptosis, providing a multi-faceted approach to cytoprotection in bone, liver, and neural tissues.
2.PRODUCT INDICATIONS
This product is indicated for preclinical research targeting Diabetic Osteoporosis, where it helps correct calcium imbalance and improve bone density in metabolic disorder models. It is also applied in studies of Ischemic Stroke for its neuroprotective and anti-inflammatory effects, as well as in Chronic Kidney Disease (CKD) and Liver Fibrosis investigations to mitigate tissue scarring and fibrotic progression. The primary user base includes researchers in endocrinology, neurology, and hepatology exploring novel therapeutic candidates for metabolic and degenerative conditions.
3.CLINICAL EFFICACY OF PRODUCT
In vivo studies demonstrate that Ligustroflavone effectively increases serum PTH and bone calcium levels, reversing trabecular bone loss in diabetic osteoporosis models. It significantly reduces cerebral infarct volume and neurological deficits in ischemic stroke by suppressing NLRP1 inflammasome activation, while also lowering markers of fibrosis (α-SMA, Col1a1) in liver and kidney injury models. These efficacy profiles support its research utility as a promising lead compound for developing treatments against bone fragility, cerebrovascular damage, and organ fibrosis.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
Hot Tags:Ligustroflavone, CaSRantagonist, Nuezhenoside, LigustrumLucidum, OsteoporosisResearch, Neuroprotection, AntiFibrosis, NaturalFlavonoid, ResearchChemical, BioactiveCompound, Supplier, Manufacturer, Bulk order, Pharmaceutical.
If you have any product requirements, please send an email to:info@huanqiukeji9.com;whatsapp:85246842553
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