Image not available
Chemicals
Prim-o-glucosylcimifugin CAS NO.80681-45-4
<p>Prim-O-glucosylcimifugin (POG) is a high-purity chromone compound naturally derived from the roots of <em>Saposhnikovia divaricata</em>(Fangfeng). As a key active ingredient, it is widely utilized in the R&D of pharmaceuticals and advanced skincare for its potent anti-inflammatory and immunomodulatory properties. This ingredient is particularly suitable for formulators targeting sensitive skin care, anti-aging se…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
Source categories
About this product
Product information from the supplier.
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Prim-o-glucosylcimifugin |
| CAS NO. | 80681-45-4 |
| Appearance | White to off-white powder |
| Molecular Formula | C22H28O11 |
| Molecular Weight | 468.45 g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in water, methanol, DMSO; slightly soluble in ethanol; insoluble in n-hexane |
| Endotoxin | < 0.1 EU/mg |
| Biological Activity | Anti-inflammatory, immunomodulatory, inhibits JAK2/STAT3 signaling pathway, reduces pro-inflammatory cytokines (TNF-α, IL-6, IL-1β), modulates MDSC activity |
| Storage Conditions | Store at -20°C, protected from light and moisture |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Prim-O-glucosylcimifugin exerts its effects primarily by inhibiting the JAK2/STAT3 signaling pathway, which leads to the downregulation of inflammatory mediators such as iNOS and COX-2. This mechanism effectively suppresses the production of pro-inflammatory cytokines like TNF-α, IL-1β, and IL-6 in macrophages. Additionally, it modulates immune cell function by targeting Myeloid-Derived Suppressor Cells (MDSCs), thereby normalizing the immune microenvironment and enhancing anti-tumor responses when combined with immunotherapies.
2.PRODUCT INDICATIONS
This product is indicated for use in anti-inflammatory formulations, immune adjuvant therapies, and high-end cosmetic applications. It is ideal for developing products targeting atopic dermatitis, psoriasis, acne-prone skin, and post-procedure soothing care. Researchers also utilize it in preclinical studies focused on cancer immunotherapy and autoimmune diseases, making it a versatile ingredient for both therapeutic and cosmetic R&D.
3.CLINICAL EFFICACY OF PRODUCT
Studies demonstrate that Prim-O-glucosylcimifugin significantly alleviates symptoms in atopic dermatitis models by inhibiting Th2 differentiation and reducing skin inflammation. In oncology research, it enhances the efficacy of PD-1 inhibitors by reducing MDSC-mediated immunosuppression, leading to increased CD8+ T-cell infiltration and tumor growth suppression. Clinical evidence supports its role in improving skin barrier function and providing robust anti-inflammatory and antioxidant benefits in topical applications.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
Hot Tags:PrimOG, PrimOglucosylcimifugin, POG #Cimifugin, Saposhnikovia, Chromone, AntiInflammatory, JAKSTAT, Immunology, SkincareScience, Supplier, Manufacturer, Bulk order, Pharmaceutical.
If you have any product requirements, please send an email to:info@huanqiukeji9.com;whatsapp:85246842553
More from this supplier
Global Technology Co., Ltd.
