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Chemicals
Plecanatide CAS NO.467426-54-6
<p>Plecanatide is a synthetic peptide analog of uroguanylin, designed as a potent activator of the intestinal guanylate cyclase-C (GC-C) receptor. It is engineered for high specificity and affinity toward GC-C, which is predominantly expressed in the intestinal epithelium. Upon binding, it stimulates intracellular cGMP production, triggering chloride and bicarbonate secretion into the intestinal lumen while reducing…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Plecanatide |
| CAS NO. | 467426-54-6 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₆₅H₁₀₄N₁₈O₂₆S₄ |
| Molecular Weight | 1681.88 g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in water and dilute acids; partially soluble in DMSO; insoluble in non-polar solvents |
| Endotoxin | ≤ 50 EU/mg (for cell culture and in vitro use; may differ by batch) |
| Biological Activity | Potent guanylate cyclase-C (GC-C) agonist; stimulates intestinal fluid secretion and accelerates transit; exhibits anti-constipation effects |
| Storage Conditions | Lyophilized powder: Store at 2–8°C in a dry, dark place; stable for 24–36 months. Reconstituted solutions: Store at -20°C, protected from light, and use within 1–2 weeks; avoid freeze-thaw cycles |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Plecanatide functions as a selective agonist of the guanylate cyclase-C (GC-C) receptor located on the luminal surface of intestinal epithelial cells. Binding activates intracellular cGMP signaling, which drives chloride and bicarbonate ion secretion into the gut lumen while inhibiting sodium absorption, resulting in osmotic water influx and accelerated intestinal transit. This mechanism directly addresses the pathophysiology of constipation by enhancing motility and hydration of stool, distinguishing it from traditional laxatives that primarily stimulate nerves or muscles.
2.PRODUCT INDICATIONS
Plecanatide is indicated for the treatment of chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C) in adults. It is also studied for potential use in other functional gastrointestinal disorders involving impaired motility or secretion. Suitable for patients unresponsive to conventional laxatives or seeking targeted, receptor-mediated therapy with fewer systemic side effects. Ideal for clinical trials, formulation development, and mechanistic studies in GI pharmacology.
3.CLINICAL EFFICACY OF PRODUCT
Clinical trials demonstrate that Plecanatide significantly increases the frequency of spontaneous bowel movements (SBMs) and improves stool consistency compared to placebo in patients with CIC and IBS-C. It also reduces straining and abdominal discomfort, with a favorable safety profile including minimal systemic absorption and low risk of electrolyte imbalance. Efficacy is consistent across multiple Phase II and III studies, supporting its regulatory approval and adoption in gastroenterology care pathways.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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If you have any product requirements, please send an email to:sales@huanqiukeji9.com;whatsapp:85244219157
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