Chemicals

Luteolin tetramethylether CAS NO.855-97-0

<p>Luteolin Tetramethylether, also known as 3&#39;,4&#39;,5,7-Tetramethoxyflavone, is a high-purity polymethoxyflavone (PMF) derivative of the natural flavonoid Luteolin. This compound is characterized by its four methoxy groups, which significantly enhance its lipophilicity and metabolic stability compared to its parent molecule. It is supplied as a fine yellow to off-white powder with HPLC purity typically ≥98%, m…

SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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Product information from the supplier.



TECHNICAL SPECIFICATIONS


Item
Specification
Product Name
Luteolin tetramethylether
CAS NO.
855-97-0
Appearance
Fine yellow to off-white crystalline powder
Molecular Formula
C19H18O6
Molecular Weight
342.34 g/mol
Purity (RP-HPLC)
≥ 98.0%
Solubility
Soluble in DMSO, methanol; slightly soluble in ethanol; insoluble in water
Endotoxin<0.1 EU/mg
Biological Activity
Potent anti-inflammatory, antioxidant, and neuroprotective activities
Storage Conditions
Store at 2–8°C, protected from light and moisture
Stock Location
Stock in USA
MOQ
1g


1.MECHANISM OF ACTION

The primary mechanism of Luteolin Tetramethylether involves the potent inhibition of key inflammatory signaling pathways and mediator release. It functions as a broad-spectrum anti-inflammatory agent by suppressing the activation of transcription factors like NF-κB and MAPK pathways, thereby reducing the expression of downstream pro-inflammatory cytokines such as TNF-α and IL-6. Notably, it exhibits strong mast cell-stabilizing properties, effectively inhibiting the release of histamine and other allergic mediators. Furthermore, it demonstrates chondroprotective effects by modulating the Wnt/β-catenin signaling pathway, which is crucial for cartilage homeostasis, and also shows activity against various microbial pathogens through mechanisms that disrupt cellular integrity.

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2.PRODUCT INDICATIONS

This product is specifically indicated for research and development applications across pharmaceuticals, nutraceuticals, and cosmetics. It serves as a critical standard for quality control in the quantification and identification of flavonoid compounds in herbal extracts and finished products. In drug discovery, it is utilized in screening for anti-allergy, anti-arthritic, and anti-metabolic disorder agents due to its targeted bioactivity. For formulation development, it is investigated as an active ingredient in skincare products aimed at soothing sensitive skin and in dietary supplements designed for joint health and inflammatory support, targeting both consumer health and clinical research audiences.

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3.CLINICAL EFFICACY OF PRODUCT

While direct human clinical trials are still expanding, extensive preclinical studies robustly support the efficacy of Luteolin Tetramethylether. Research highlights its superior anti-inflammatory and anti-allergic potency compared to unmethylated luteolin, showing significant inhibition of human mast cell degranulation, which is relevant for allergy and asthma management. In models of cartilage degradation and osteoarthritis, it has demonstrated chondroprotective effects by reducing inflammatory damage to joint tissues. Its broad-spectrum antimicrobial and antifungal activities further validate its potential therapeutic utility, establishing it as a promising candidate for further clinical development in immune and inflammatory conditions.

4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.


Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.


We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards


Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods 

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.


We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.


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If you have any product requirements, please send an email to:info@huanqiukeji9.com;whatsapp:85246842553