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Chemicals
Ularitide Acetate CAS NO.118812-69-4
<p>Ularitide Acetate is a synthetic analog of urodilatin, belonging to the natriuretic peptide family. It is primarily utilized in cardiovascular and renal research as a potent vasodilator and natriuretic agent. This high-purity peptide is critical for preclinical studies targeting acute decompensated heart failure (ADHF) and renal dysfunction, offering researchers a reliable tool to investigate hemodynamic regulati…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Ularitide Acetate |
| CAS NO. | 118812-69-4 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₁₄₅H₂₃₄N₅₂O₄₄S₃ |
| Molecular Weight | 3463.3 g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in water and dilute acidic solutions |
| Endotoxin | ≤1 EU/mg |
| Biological Activity | Potent natriuretic, diuretic, and vasodilatory activity via NPR-A activation |
| Storage Conditions | Store at -20°C, protected from light and moisture |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Ularitide exerts its effects by binding to natriuretic peptide receptor A (NPRA), activating guanylyl cyclase to increase intracellular cyclic guanosine monophosphate (cGMP) levels. This signaling cascade leads to systemic and renal vasodilation, inhibition of the renin-angiotensin-aldosterone system (RAAS), and suppression of sympathetic nervous system activity. The result is a reduction in cardiac preload and afterload, coupled with enhanced sodium and water excretion (natriuresis and diuresis) without significant renal impairment.
2.PRODUCT INDICATIONS
This product is indicated for research in acute decompensated heart failure (ADHF), where it is used to study rapid hemodynamic improvement and decongestion. It is also applied in investigations of acute kidney injury (AKI) and refractory ascites in cirrhosis, targeting mechanisms of renal protection and fluid overload management. The primary user base includes cardiovascular pharmacologists, nephrology researchers, and pharmaceutical R&D teams focused on peptide-based therapeutic development.
3.CLINICAL EFFICACY OF PRODUCT
Clinical trials, such as the TRUE-AHF study, demonstrated that Ularitide infusion significantly reduces pulmonary capillary wedge pressure (PCWP), improves dyspnea scores, and lowers NT-proBNP levels within hours of administration. While it effectively achieves acute hemodynamic decompression and is well-tolerated, large-scale outcomes trials have not shown a statistically significant reduction in long-term cardiovascular mortality or heart failure rehospitalization rates compared to placebo.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
Hot Tags: Ularitide #UlaritideAcetate #NatriureticPeptide #HeartFailureTreatment #Vasodilator #ResearchPeptide #CardiovascularResearch #RenalResearch #ADHF #cGMP #NPRAgonist #PeptideTherapeutics
If you have any product requirements, please send an email to:support@huanqiukeji9.com;whatsapp:85296236544
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Global Technology Co., Ltd.
