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Chemicals
Adrenomedullin (rat) CAS NO.161383-47-7
<p>Adrenomedullin (rat) is a 50-amino acid bioactive peptide belonging to the calcitonin gene-related peptide (CGRP) superfamily, originally isolated from rat adrenal medulla. It functions as a potent endogenous vasodilator with significant roles in regulating cardiovascular and renal physiology. This research-grade peptide is essential for studying mechanisms of hypertension, heart failure, and renal dysfunction in…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Adrenomedullin (rat) |
| CAS NO. | 161383-47-7 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₂₄₂H₃₈₁N₇₇O₇₅S₅ |
| Molecular Weight | 5729.49 g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water and dilute acidic solutions |
| Endotoxin | ≤1 EU/mg (or as per customer specification) |
| Biological Activity | Potent vasodilatory, natriuretic, and cardioprotective effects in rodent models |
| Storage Conditions | Store at -20°C or below, protected from light and moisture |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
The peptide exerts its effects by binding to G protein-coupled receptors composed of CLR (calcitonin receptor-like receptor) and RAMP2/3 (Receptor Activity-Modifying Proteins), activating adenylate cyclase to increase intracellular cAMP levels. This signaling cascade promotes nitric oxide (NO) release from endothelial cells, leading to vasodilation. Additionally, it inhibits aldosterone secretion and the renin-angiotensin system (RAS), resulting in reduced vascular resistance, increased renal blood flow, and enhanced natriuresis without triggering reflex tachycardia.
2.PRODUCT INDICATIONS
Adrenomedullin (rat) is primarily indicated for experimental research in cardiovascular and renal diseases, including hypertension, congestive heart failure (CHF), and pulmonary arterial hypertension (PAH). It is also used in studies of septic shock for its vasodilatory and anti-inflammatory properties, as well as in investigations of vascular remodeling and angiogenesis. This product is targeted at basic science researchers, pharmacologists, and biotech R&D teams focusing on peptide therapeutics and rodent disease models.
3.CLINICAL EFFICACY OF PRODUCT
In rodent models of heart failure and hypertension, Adrenomedullin infusion consistently demonstrates rapid hemodynamic improvement, including reduced systemic and pulmonary arterial pressure, improved cardiac output, and normalized renal perfusion. It effectively attenuates cardiac hypertrophy and fibrosis while protecting against acute kidney injury by reducing oxidative stress and inflammation. Although human recombinant forms are in clinical trials, the rat-specific peptide remains a gold standard for validating therapeutic efficacy and safety in murine systems.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
Hot Tags: Adrenomedullin #RatAdrenomedullin #VasodilatorPeptide #CardiorenalResearch #HypertensionResearch #HeartFailureModel #ResearchPeptide #SepticShock #CGRPfamily #cAMP
If you have any product requirements, please send an email to:support@huanqiukeji9.com;whatsapp:85296236544
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