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Chemicals
Angiotensin Converting Enzyme Inhibitor CAS NO.35115-60-7
<p>Angiotensin Converting Enzyme Inhibitor (Teprotide, SQ 20881) is a nonapeptide ACE inhibitor originally derived from the venom of the snake <em>Bothrops jararaca</em>. As the first discovered peptide inhibitor of ACE, it serves as a prototypical research tool for studying the renin-angiotensin system (RAS). This high-purity synthetic compound is designed for biochemical and pharmacological research, enabling scie…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Angiotensin Converting Enzyme Inhibitor |
| CAS NO. | 35115-60-7 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₅₃H₇₇N₁₄O₁₂ |
| Molecular Weight | 1136.3 g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in water, dilute acidic solutions; insoluble in organic solvents |
| Endotoxin | < 0.1 EU/mg (by LAL assay) |
| Biological Activity | Potent inhibitor of Angiotensin-Converting Enzyme (ACE); reduces Angiotensin II formation |
| Storage Conditions | Lyophilized: 2–8°C, protected from light; reconstituted: store at -20°C (stable for up to 1 month) |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Teprotide functions as a potent competitive inhibitor of angiotensin-converting enzyme (ACE), binding directly to the active site of the enzyme with high affinity. This binding effectively blocks the proteolytic cleavage of Angiotensin I, preventing the generation of Angiotensin II and the subsequent vasoconstrictive and aldosterone-releasing effects. Additionally, it potentiates the vasodilatory and hypotensive effects of bradykinin by inhibiting its degradation, providing a dual mechanism for blood pressure regulation in research settings.
2.PRODUCT INDICATIONS
This inhibitor is indicated for in vitro and in vivo research applications focused on hypertension, cardiovascular disease, and renal physiology. It is utilized by researchers to elucidate the role of ACE in disease models, screen for novel antihypertensive agents, and study the pathophysiology of the RAS. The product is essential for academic institutions, pharmaceutical R&D departments, and contract research organizations (CROs) engaged in metabolic and cardiovascular drug discovery.
3.CLINICAL EFFICACY OF PRODUCT
Although Teprotide itself is not used clinically, it served as the foundational molecule for the development of orally active ACE inhibitor drugs such as Captopril and Enalapril. In preclinical studies, it demonstrates significant efficacy in reducing blood pressure in hypertensive animal models, validating the ACE pathway as a critical target for antihypertensive therapy. Research using this peptide has been instrumental in establishing the therapeutic principles of modern RAS blockade.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
Hot Tags: Teprotide #ACEInhibitor #ReninAngiotensinSystem #HypertensionResearch #CardiovascularResearch #BPP9a #SQ20881 #ResearchPeptide #EnzymeInhibitor #RASPathway
If you have any product requirements, please send an email to:support@huanqiukeji9.com;whatsapp:85296236544
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