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Chemicals
[D-Lys16]-ACTH（1-24）CAS NO.494750-52-6
<p>[D-Lys16]-ACTH (1-24) is a synthetic peptide analog of adrenocorticotropic hormone (ACTH) featuring a D-lysine substitution at position 16. This structural modification enhances its stability against enzymatic degradation compared to the native hormone, making it a valuable tool for research into the hypothalamic-pituitary-adrenal (HPA) axis. It is widely used in neuroendocrinology and pharmacology studies to inv…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | [D-Lys16]-ACTH（1-24） |
| CAS NO. | 494750-52-6 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₁₃₆H₂₁₀N₄₀O₃₁S |
| Molecular Weight | 3017.4 g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water, acidic aqueous solutions; insoluble in non-polar solvents |
| Endotoxin | ≤1 EU/mg (LAL test) |
| Biological Activity | Potent agonist of melanocortin 2 receptor (MC2R), stimulates adrenal steroidogenesis |
| Storage Conditions | Store at -20°C, protected from light and moisture; avoid repeated freeze-thaw cycles |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
The peptide acts as a potent agonist of melanocortin 2 receptors (MC2R) located on adrenal cortex cells. Upon binding, it activates adenylate cyclase, leading to an increase in intracellular cAMP levels. This signaling cascade stimulates the synthesis and secretion of corticosteroids, primarily cortisol, from the adrenal glands. The D-amino acid substitution helps maintain biological activity while potentially altering receptor interaction kinetics for specialized research applications.
2.PRODUCT INDICATIONS
This product is indicated for scientific research purposes only, including studies on adrenal insufficiency, stress response mechanisms, and HPA axis dysregulation. It serves as a critical reagent in the development of diagnostic agents, such as contrast media for imaging, and is utilized in structure-activity relationship (SAR) studies to design novel peptide therapeutics targeting melanocortin receptors.
3.CLINICAL EFFICACY OF PRODUCT
In preclinical research settings, [D-Lys16]-ACTH (1-24) has demonstrated efficacy in stimulating adrenal steroidogenesis, effectively elevating plasma cortisol levels in animal models. Its enhanced metabolic stability allows for prolonged in vivo effects, supporting its use as a reliable standard in adrenal function testing and as a lead compound in the development of long-acting ACTH analogs for investigative use.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
Hot Tags: ACTHpeptide #DLys16ACTH #HPAaxis #AdrenalResearch #MC2Ragonist #ResearchPeptide #Neuroendocrinology #PeptideAnalog
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