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Chemicals
α-Conotoxin EI CAS NO.170663-33-9
<p>α-Conotoxin EI is a highly selective 16-amino acid neurotoxic peptide originating from the venom of the fish-hunting cone snail <em>Conus ermineus</em>. Characterized by its compact two-disulfide bridge framework, it functions as a precise pharmacological probe for nicotinic acetylcholine receptors (nAChRs). This research-grade toxin is primarily utilized in neuroscience to dissect the subunit composition and fun…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | α-Conotoxin EI |
| CAS NO. | 170663-33-9 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C83H123N27O27S5 |
| Molecular Weight | 2112.3g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water, 0.1 M acetic acid, or 50% acetonitrile/H₂O (0.1% TFA) |
| Endotoxin | ≤1 EU/mg |
| Biological Activity | Potent and selective antagonist of muscle-type nicotinic acetylcholine receptors (nAChR α1β1δε), used to study neuromuscular transmission and receptor subtype discrimination |
| Storage Conditions | Store at -20°C, protected from light and moisture; avoid repeated freeze-thaw cycles |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
The peptide exerts its effects by selectively antagonizing the interface between the α1 and δ subunits of the muscle-type nAChR (α1β1δε). It binds with high affinity to the orthosteric site, physically obstructing acetylcholine binding and preventing cation influx. This competitive blockade leads to a reversible inhibition of neuromuscular transmission, resulting in flaccid paralysis in experimental models. Its exquisite subtype selectivity allows researchers to isolate the contribution of muscle-type receptors without significant cross-reactivity with neuronal isoforms.
2.PRODUCT INDICATIONS
This product is indicated for research applications in diabetes mellitus, focusing on beta-cell function assessment, diabetic nephropathy, neuropathy, and cardiovascular complications in rat models. It is used to develop and validate rat-specific ELISA kits, study islet transplantation outcomes, and investigate the physiological effects of C-peptide replacement therapy in type 1 diabetes research. The target audience includes endocrinologists, physiologists, and pharmaceutical researchers specializing in metabolic diseases.
3.CLINICAL EFFICACY OF PRODUCT
In preclinical research, α-Conotoxin EI demonstrates potent and rapid blockade of nerve-evoked muscle contractions in isolated tissue preparations, with efficacy quantified by IC50 values in the low nanomolar range. While not used directly in human therapy, its high potency and selectivity validate its role as a gold-standard tool for characterizing nAChR function and screening for novel modulators with potential therapeutic applications in anesthesiology or neuromuscular diseases.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
Hot Tags: Conotoxin, #αConotoxinEI, #NicotinicAcetylcholineReceptor, #nAChRAntagonist, #PeptideResearch, #NeurotoxinTool, #PharmacologicalProbe, #NeuroscienceReagent, #MuscleTypenAChR, #DrugDiscoveryPeptide
If you have any product requirements, please send an email to:support@huanqiukeji9.com;whatsapp:85296236544
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Global Technology Co., Ltd.
