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Chemicals
[D-Phe7]-Bradykinin CAS NO.97825-00-8
<p>[D-Phe⁷]-Bradykinin is a synthetic 9-amino acid bradykinin analog with a key D-phenylalanine substitution at position 7. This modification converts it from a full agonist into a <strong>partial agonist/antagonist</strong> at the B₂ bradykinin receptor (B₂R), offering unique utility for dissecting kinin signaling pathways. It is widely used in cardiovascular, inflammation, and pain research to study receptor speci…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | [D-Phe7]-Bradykinin |
| CAS NO. | 97825-00-8 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₅₀H₇₃N₁₅O₁₂ |
| Molecular Weight | 1084.2g/mol |
| Purity (RP-HPLC) | ≥95% |
| Solubility | Soluble in water, dilute acetic acid, or 0.1% TFA in water; insoluble in organic solvents like DMSO or acetonitrile without modifiers |
| Endotoxin | ≤1 EU/mg |
| Biological Activity | Partial agonist/antagonist at B₂ bradykinin receptor; reduces bradykinin-induced vasodilation and edema in preclinical models |
| Storage Conditions | Store at -20°C, protected from light and moisture; avoid repeated freeze-thaw cycles |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
The peptide binds to the B₂ receptor but, due to the D-Phe⁷ substitution, induces a suboptimal conformational change that reduces Gq/11 coupling efficiency. It acts as a competitive partial agonist: at low concentrations or in naive tissues, it may weakly stimulate phospholipase C (PLC), IP₃, and calcium release, mimicking bradykinin's vasodilatory and pro-inflammatory effects. At higher concentrations or in pre-stimulated systems, it occupies receptors without full activation, effectively blocking endogenous bradykinin and attenuating downstream nitric oxide (NO) and prostaglandin production
2.PRODUCT INDICATIONS
This analog is indicated for research requiring modulation rather than full activation of the kinin system. It is used to: (1) study B₂ receptor desensitization and trafficking; (2) probe the role of kinins in hypertension, septic shock, and angioedema through partial blockade; (3) serve as a precursor scaffold for developing more potent antagonists (e.g., icatibant analogs); and (4) investigate tissue-specific receptor subtypes in smooth muscle and neuronal preparations
3.CLINICAL EFFICACY OF PRODUCT
In preclinical models, [D-Phe⁷]-Bradykinin demonstrates graded efficacy depending on the system: it can elicit weak vasodilation or bronchoconstriction but effectively suppresses bradykinin-induced hypotension and plasma extravasation when administered as a pretreatment. Its partial agonist profile helps researchers quantify receptor reserve and allosteric modulation, providing critical data for developing clinical-grade B₂ antagonists for hereditary angioedema and inflammatory pain
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
Hot Tags: DPhe7Bradykinin #BradykininAnalog #B2ReceptorAntagonist #KininSystem #PartialAgonist #VascularResearch #InflammationResearch #PeptideModulator
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