Image not available
Chemicals
Dabcyl-KTSAVLQSGFRKME-Edans CAS NO.730985-86-1
<p>Dabcyl-KTSAVLQSGFRKME-Edans is a fluorogenic peptide substrate specifically designed for detecting and measuring the activity of coronavirus main protease (Mpro/3CLpro). Featuring a Dabcyl-Edans FRET pair, it remains quenched when intact but emits strong fluorescence upon cleavage by the viral enzyme, making it an essential tool for high-throughput screening of antiviral inhibitors and enzymatic kinetic studies i…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
Source categories
About this product
Product information from the supplier.
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Dabcyl-KTSAVLQSGFRKME-Edans |
| CAS NO. | 730985-86-1 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₉₅H₁₄₁N₂₅O₂₄S₂ |
| Molecular Weight | 2132.4g/mol |
| Purity (RP-HPLC) | ≥95% |
| Solubility | Soluble in DMSO, DMF; sparingly soluble in water |
| Endotoxin | ≤1 EU/mg |
| Biological Activity | Strong fluorescence increase upon cleavage by SARS-CoV-2 3CLpro (Main Protease) |
| Storage Conditions | Store at -20°C, protected from light. Avoid repeated freeze-thaw cycles. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
This substrate operates on the principle of fluorescence resonance energy transfer (FRET), where the N-terminal Dabcyl (quencher) suppresses the fluorescence of the C-terminal Edans (fluorophore) in the uncleaved state. When the SARS-CoV-2 3CL protease cleaves the peptide bond between Gln (Q) and Ser (S), the fluorophore is released, resulting in a measurable increase in fluorescence intensity at Ex/Em ~340/490 nm, which is directly proportional to protease activity.
2.PRODUCT INDICATIONS
It is primarily used in biochemical assays to study the replication mechanism of coronaviruses, including SARS-CoV-2. Researchers utilize this substrate in drug discovery to screen and characterize potential 3CL protease inhibitors, evaluate enzyme kinetics, and monitor viral protease activity in vitro, aiding the development of treatments for COVID-19 and related viral infections.
3.CLINICAL EFFICACY OF PRODUCT
While not a therapeutic agent itself, this substrate demonstrates high sensitivity and reliability in preclinical settings, with a well-defined Km value enabling accurate assessment of inhibitor potency (IC50). It has been widely adopted in pharmaceutical and academic labs for validating the efficacy of lead compounds like nirmatrelvir and GC376, supporting the rapid development of antiviral drugs.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
Hot Tags: DabcylKTSAVLQSGFRKMEEdans, #3CLprotease, #SARS-CoV-2, #Mpro, #FRETsubstrate, #fluorogenicpeptide, #coronavirusresearch, #antiviral, #COVID19, #enzymeassay, #highthroughputscreening, #drugdiscovery, #infectiousdisease, #biochemicalassay
If you have any product requirements, please send an email to:support@huanqiukeji9.com;whatsapp:85244969439
More from this supplier
Global Technology Co., Ltd.
