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Chemicals
[Cys(Acm)20,31]-EGF (20-31) CAS NO.89991-90-2
<p>[Cys(Acm)20,31]-EGF (20-31) is a stabilized 12-amino acid fragment derived from the mouse Epidermal Growth Factor sequence, encompassing the critical receptor-binding region (residues 20–31). This synthetic peptide features Acetamidomethyl (Acm) protection on both cysteine residues, which prevents unwanted disulfide bond formation and enhances stability for experimental use. It retains key biological properties o…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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Product information from the supplier.
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | [Cys(Acm)20,31]-EGF (20-31) |
| CAS NO. | 89991-90-2 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₆₃H₉₈N₁₆O₂₃S₃ |
| Molecular Weight | 1635.7g/mol |
| Purity (RP-HPLC) | ≥98% |
| Solubility | Soluble in 1M acetic acid or deionized water |
| Endotoxin | ≤1 EU/mg |
| Biological Activity | Binds to EGFR; used in receptor binding studies |
| Storage Conditions | Store at -20°C, protected from light |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
The peptide functions as a partial agonist or competitive ligand for the Epidermal Growth Factor Receptor (EGFR). It specifically binds to the extracellular domain of EGFR, mimicking the native EGF interaction, which can lead to receptor dimerization and activation of intrinsic tyrosine kinase activity. This triggers downstream signaling cascades such as MAPK and PI3K/Akt, promoting cellular responses like DNA synthesis and proliferation. The Acm modification on Cys20 and Cys31 allows researchers to study receptor engagement without the complexity of full disulfide bridging, facilitating precise structure-function studies.
2.PRODUCT INDICATIONS
This product is indicated for research use only, specifically in biochemical and cell-based assays investigating EGFR-mediated processes. It is suitable for competitive binding studies, mitogenicity assays, wound healing models, and as a standard in drug discovery screens targeting the EGFR pathway. It is targeted at academic researchers, pharmaceutical R&D scientists, and CROs working on cancer biology, tissue regeneration, and growth factor signaling, providing a cost-effective and stable alternative to full-length EGF for specific experimental applications.
3.CLINICAL EFFICACY OF PRODUCT
As a research-grade biochemical reagent, this peptide is not intended for direct clinical or therapeutic application. Its efficacy is demonstrated in experimental settings, where it serves as a potent tool for elucidating EGFR ligand-receptor dynamics and validating anti-EGFR strategies. In pre-clinical research, it has shown utility in mimicking EGF's proliferative effects in vitro, aiding in the development of targeted therapies and diagnostic agents for EGFR-overexpressing cancers and regenerative medicine approaches.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
Hot Tags: EGFfragment, #EGFRbinding, #CysAcmPeptide, #GrowthFactorResearch, #ReceptorBindingDomain, #SignalTransduction, #ResearchPeptide, #CellProliferationAssay, #EGFanalog, #BiochemicalReagent
If you have any product requirements, please send an email to:support@huanqiukeji9.com;whatsapp:85244969439
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Global Technology Co., Ltd.
