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Chemicals
Endothelin 2 (human, canine) CAS NO.123562-20-9
<p>Endothelin 2 (human, canine) is a potent 21-amino acid vasoactive peptide that plays a critical role in regulating vascular tone and cellular proliferation. As one of the three known endothelin isoforms, it is widely utilized in cardiovascular and oncology research to study pathological mechanisms related to hypertension, atherosclerosis, and tumor microenvironment regulation. This high-purity reagent is essentia…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Endothelin 2 (human, canine) |
| CAS NO. | 123562-20-9 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₁₁₅H₁₆₀N₂₆O₃₂S₄ |
| Molecular Weight | 2509.5g/mol |
| Purity (RP-HPLC) | ≥98% |
| Solubility | Soluble in 1M acetic acid, DMSO, or deionized water |
| Endotoxin | ≤1 EU/mg |
| Biological Activity | Potent vasoconstrictor; binds to ETA and ETB receptors |
| Storage Conditions | Store at -20°C, protected from light and moisture |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Endothelin 2 exerts its biological effects by binding to two G-protein coupled receptors, ETA and ETB, with high affinity. Activation of ETA receptors on vascular smooth muscle cells triggers a signaling cascade involving phospholipase C and inositol triphosphate, leading to a rapid increase in intracellular calcium and sustained vasoconstriction. Concurrently, its interaction with ETB receptors on endothelial cells can modulate nitric oxide release and mediate peptide clearance, creating a complex regulatory network that influences both vascular contraction and inflammatory responses in research models.
2.PRODUCT INDICATIONS
This product is indicated for Research Use Only (RUO), specifically targeting studies in cardiovascular physiology, pulmonary hypertension, and cancer biology. It is an ideal reagent for in vitro assays measuring vascular smooth muscle contraction, cell proliferation, and migration, as well as for in vivo models of ischemic injury and tumor angiogenesis. Researchers in pharmaceutical development also utilize it as a reference standard for screening and validating endothelin receptor antagonists aimed at treating fibrotic and cardiovascular diseases.
3.CLINICAL EFFICACY OF PRODUCT
Although not for therapeutic application, Endothelin 2 demonstrates high preclinical efficacy in establishing robust experimental models of endothelial dysfunction and vasospasm. Its potent and long-lasting vasoconstrictive activity provides a reliable positive control for evaluating the inhibitory effects of candidate drugs, thereby accelerating the discovery of treatments for conditions like resistant hypertension and chronic kidney disease where the endothelin pathway is dysregulated.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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Global Technology Co., Ltd.
