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Chemicals
Oroxylin A 7-O-glucuronide CAS NO.36948-76-2
<p>Oroxylin A 7-O-glucuronide, also widely known as Oroxyloside, is a naturally occurring flavonoid glucuronide metabolite primarily isolated from the dried roots of Scutellaria baicalensis (Chinese skullcap). Presented as an off-white to yellow solid, this orally active compound serves as a crucial phytochemical intermediate and research reagent for scientists delving into natural product pharmacology, particularly…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Oroxylin A 7-O-glucuronide |
| CAS NO. | 336948-76-2 |
| Appearance | Off-white to light yellow powder |
| Molecular Formula | C22H20O11 |
| Molecular Weight | 460.39 g/mol |
| Purity (RP-HPLC) | ≥98% |
| Solubility | Soluble in water, DMSO; insoluble in ethanol, acetone, chloroform |
| Endotoxin | ≤10 EU/mg |
| Biological Activity | Anti-tumor activity; Anti-inflammatory; Neuroprotective effects |
| Storage Conditions | -20°C, protected from light, dry and sealed |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
The principal mechanism of action of Oroxylin A 7-O-glucuronide involves the sophisticated modulation of key intracellular signaling cascades to exert its anti-inflammatory, anti-tumor, and hepatoprotective effects. It actively inhibits the phosphorylation of JNK and blocks the nuclear translocation of NF-κB p65, while simultaneously upregulating the expression of PPARγ, thereby significantly reducing the production of pro-inflammatory cytokines such as IL-1β and IL-6. Furthermore, it interferes with angiogenic processes by reducing the autophosphorylation of VEGFR2 (Flk-1) and modulating associated proteins like R-Ras and VE-cadherin, and it additionally exhibits inhibitory activity against prolyl oligopeptidase (POP), contributing to its multifaceted regulatory impact on cellular physiology and pathology.
2.PRODUCT INDICATIONS
This product is strictly indicated for laboratory research, preclinical pharmacological assays, and analytical method development, making it an indispensable asset for a wide array of scientific disciplines and professional users. It is ideal for researchers exploring novel therapeutics for glioma, liver cancer, and inflammatory bowel disease (colitis), as well as for formulators and QC labs in the botanical industry needing a reliable chemical marker to ensure the potency and consistency of Scutellaria radix extracts alongside baicalin and wogonoside. Additionally, it caters to biochemists studying enzyme kinetics related to glycosidases and hemolysins, and to toxicologists evaluating the metabolic profiles and safety parameters of flavonoid-rich herbal preparations in controlled in vitro and in vivo models.
3.CLINICAL EFFICACY OF PRODUCT
As a raw research chemical and natural metabolite, Oroxylin A 7-O-glucuronide is not a standalone clinically approved drug and therefore lacks direct clinical efficacy for administration to human or animal patients. However, robust preclinical in vitro and in vivo studies validate its potent bioactivity, demonstrating significant anti-tumor growth and metastasis suppression in glioma and liver cancer xenograft models, alongside remarkable protective effects against drug-induced liver injury (such as acetaminophen-induced hepatotoxicity) and chemically induced colitis in murine models. These research outcomes highlight its value as a lead compound for drug discovery targeting cancer and inflammatory diseases, and as a critical reference standard for the quality control of botanical pharmaceuticals, rather than a finished therapeutic agent.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
Hot Tags: Oroxylin A 7-O-glucuronide, Oroxyloside, Oroxylin A-7-O-β-D-glucuronide, Scutellaria baicalensis metabolite, Flavonoid glucuronide, Anti-inflammatory phytochemical, Anti-angiogenic compound, PPARγ activator, NF-κB inhibitor, Herbal reference standard
If you have any product requirements, please send an email to:sales@huanqiukeji9.com;whatsapp:85244219157
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