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Chemicals
Big Endothelin-1 Fragment (22-38) (human) CAS NO.124932-61-2
<p>Big Endothelin-1 Fragment (22-38), human is a synthetic 17-amino acid peptide representing the C-terminal fragment of Big ET-1, the precursor to the potent vasoconstrictor Endothelin-1. This research-grade peptide is widely used as a biochemical tool to study the processing and metabolism of the endothelin system, particularly in models of cardiovascular and pulmonary physiology, providing insights into enzyme ki…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Big Endothelin-1 Fragment (22-38) (human) |
| CAS NO. | 124932-61-2 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₈₀H₁₂₅N₂₃O₂₅ |
| Molecular Weight | 1839.0g/mol |
| Purity (RP-HPLC) | ≥98% |
| Solubility | Soluble in 1M acetic acid, DMSO, or deionized water |
| Endotoxin | ≤1 EU/mg |
| Biological Activity | Substrate analog for endothelin-converting enzyme (ECE); used to study Big ET-1 processing and maturation |
| Storage Conditions | Store at -20°C, protected from light and moisture |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
The peptide serves as a substrate analog for endothelin-converting enzyme (ECE) and other proteases involved in the maturation of Big ET-1 into active ET-1. By mimicking the natural C-terminal region of the precursor, it allows researchers to investigate the enzymatic cleavage mechanisms that regulate the production of vasoactive endothelins, thereby modulating vascular tone and tissue remodeling processes in experimental settings.
2.PRODUCT INDICATIONS
This fragment is indicated for in vitro and ex vivo research applications focused on endothelin biosynthesis and cardiovascular pathophysiology. It is particularly valuable for scientists studying hypertension, pulmonary arterial hypertension, and heart failure, where understanding the conversion of Big ET-1 to ET-1 is critical for elucidating disease mechanisms and screening for potential enzyme inhibitors.
3.CLINICAL EFFICACY OF PRODUCT
Although not intended for clinical use, Big Endothelin-1 (22-38) has demonstrated significant utility in preclinical research as a reference standard for validating endothelin-converting enzyme activity. Studies have shown its ability to be metabolized in vascular and pulmonary systems, leading to the release of prostacyclin and other mediators, confirming its relevance in modeling endothelial dysfunction and testing pharmacological interventions.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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