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Chemicals
Oxymatrine CAS NO.16837-52-8
<p><strong>Oxymatrine</strong> is a high-purity quinolizidine alkaloid extracted from the roots of <em>Sophora flavescens</em>(Kushen), supplied as a white or off-white crystalline powder primarily intended for pharmaceutical R&D, hepatology research, and botanical standardization. This water-soluble compound serves as a critical reference standard for HPLC analysis of traditional Chinese medicines and a vital t…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Oxymatrine |
| CAS NO. | 16837-52-8 |
| Appearance | White to off-white crystalline powder |
| Molecular Formula | C15H24N2O2 |
| Molecular Weight | 264.36 g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in H2O, Methanol, Ethanol, Chloroform; slightly soluble in Ether |
| Endotoxin | < 10 EU/mg |
| Biological Activity | Quinolizidine alkaloid with potent anti-inflammatory, anti-fibrotic, anti-viral (HBV), and anti-tumor effects; inhibits iNOS expression and TGF-β/Smad signaling pathway. |
| Storage Conditions | Store at 2-8°C or -20°C, protected from light and moisture. Keep container tightly sealed |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Oxymatrine exerts its diverse pharmacological effects by modulating multiple intracellular signaling cascades, most notably inhibiting the TGF-β1/Smad signaling pathway to suppress the activation of hepatic stellate cells and subsequent collagen deposition, thereby preventing liver and cardiac fibrosis. It potently reduces inflammation by downregulating the NF-κB and TLR4/MyD88 pathways, which decreases the production of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6, while simultaneously scavenging reactive oxygen species (ROS) to protect cells from oxidative stress-induced apoptosis. Additionally, the compound exhibits antiviral activity against Hepatitis B Virus (HBV) by interfering with viral DNA replication and protein expression, and it induces cancer cell death through the promotion of apoptosis and autophagy via the regulation of Bcl-2 family proteins and the PI3K/Akt/mTOR signaling axis.
2.PRODUCT INDICATIONS
Oxymatrine is indicated for non-clinical research and pharmaceutical development applications focusing on hepatology, virology, and oncology, where it is utilized to screen for anti-fibrotic agents and evaluate the efficacy of potential chronic hepatitis B treatments. Researchers employ this compound to investigate liver regeneration, viral replication inhibition, and the chemopreventive effects against various carcinomas, including liver, gastric, and prostate cancers, in cellular assays and animal models. Furthermore, it serves as a primary pharmaceutical intermediate and reference standard for quality control laboratories analyzing Sophoraspecies extracts, catering to professionals in drug discovery, traditional medicine modernization, and the development of nutraceuticals aimed at supporting liver health and metabolic function.
3.CLINICAL EFFICACY OF PRODUCT
Oxymatrine has demonstrated significant efficacy in extensive preclinical and clinical evaluations, showing a robust ability to improve liver function and increase the seroconversion rates of HBeAg and HBV DNA negativity in patients with chronic hepatitis B, often performing comparably to or synergistically with interferon therapies. In experimental models of liver fibrosis, administration of the compound significantly reduced the expression of alpha-smooth muscle actin (α-SMA) and Type I collagen, effectively halting the progression of cirrhosis without overt toxicity at therapeutic doses. Moreover, it has proven effective in ameliorating renal fibrosis, reducing myocardial injury in ischemia-reperfusion models, and inhibiting the proliferation of various tumor cell lines by inducing G0/G1 cell cycle arrest and mitochondrial-dependent apoptosis, establishing its multitarget therapeutic potential across hepatic, renal, and cardiovascular pathologies.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
HotTags:Oxymatrine, Kushen, Sophora Flavescens, Quinolizidine Alkaloid, Anti-fibrotic, Antiviral, Anti-inflammatory, Liver Protection, Hepatitis B, TGF-beta Inhibitor, NF-kappaB Inhibitor, Natural Product, Pharmaceutical Intermediate, Research Standard
If you have any product requirements, please send an email to:consult@huanqiukeji9.com;whatsapp:+34 686532411
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