LysAla3Bradykinin CAS 103545182 China Suppliers Factory

High-purity Lys-Ala3-Bradykinin (CAS 103545-18-2) produced by leading China factory. As a selective B2 receptor agonist, this synthetic peptide is ideal for cardiovascular and inflammatory research. Contact our expert suppliers for pharmaceutical-grade quality and global delivery.

SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com

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About this product

Product information from the supplier.

Lys-(Ala3)-Bradykinin (CAS NO. 103545-18-2) is a high-precision synthetic peptide analog designed as a potent and selective B2 receptor agonist. Engineered for advanced pharmacological research, this decapeptide features a strategic Ala3 substitution and N-terminal lysine extension, significantly enhancing its metabolic stability and receptor affinity compared to native Bradykinin. It serves as a critical tool for scientists investigating the kallikrein-kinin system, inflammatory pain pathways, and cardiovascular regulation.

By triggering intracellular signal transduction cascades via Gq/11 protein activation and phospholipase C (PLC) stimulation, this reagent enables the detailed study of calcium flux and the release of pro-inflammatory mediators. Ideal for in vitro laboratory research, receptor binding assays, and preclinical pharmacological studies, Lys-(Ala3)-Bradykinin provides the reliability and purity required for high-impact drug discovery and the development of novel modulators for inflammatory and cardiovascular disorders.

Detailed Parameters

Product Name	Lys-(Ala3)-Bradykinin	CAS NO.	103545-18-2
Molecular Formula	C54H83N17O12	Molecular Weight	1162.37 g/mol
Purity (RP-HPLC)	≥99.0%	Appearance	White to off-white lyophilized powder
Endotoxin	≤0.5 EU/mg	Solubility	Soluble in water or dilute acetic acid
Storage Conditions	-20°C, dry, dark, well-sealed	Stock Location	USA

Key Advantages

Ultra-High Purity

Guaranteed ≥99.0% purity via RP-HPLC, ensuring consistent and reproducible results in sensitive receptor binding assays.

Enhanced Stability

The Ala3 substitution confers superior metabolic resistance, prolonging interaction time with target receptors.

Selective Agonism

Acts as a highly selective B2 receptor probe, reducing off-target noise in GPCR signaling research.

Proven Efficacy

Validated in preclinical studies for inducing vascular relaxation and stimulating prostaglandin synthesis.

Rigorous QC

Each batch is accompanied by COA, HPLC purity reports, and MS chromatograms for full transparency.

Rapid Global Delivery

Strategically stocked in the USA and shipped via DHL/FedEx to ensure cold-chain integrity and speed.

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Management Platforms

GMP Production

Manufacturing follows strict GMP-compliant systems for high-grade pharmaceutical intermediates.

Quality Control

Standardized processes from raw material procurement to final peptide purification.

Batch Traceability

Full traceability data provided for every lot to ensure research consistency.

Cold-Chain Logistics

Professional secure packaging designed to prevent freeze-thaw degradation.

Scale Flexibility

Ability to supply from gram-level laboratory samples to ton-level industrial quantities.

Regulatory Compliance

Adherence to international trade standards and FDA/DMF certified partner laboratories.

Research Value Comparison

Feature	Native Bradykinin	Lys-(Ala3)-Bradykinin
Metabolic Stability	Low (Rapidly degraded)	High (Resistant to ACE)
Receptor Selectivity	General B1/B2	Selective B2 Agonist
Half-life in Assay	Short	Prolonged
Binding Affinity	Standard	Enhanced/Modified
Research Utility	Baseline Study	Advanced Mechanism Probe

Frequently Asked Questions

Q: What is the primary application of Lys-(Ala3)-Bradykinin in pharmaceutical research?

It is primarily used as a selective B2 receptor agonist to study inflammatory pain, cardiovascular regulation, and G-protein coupled receptor (GPCR) signaling pathways in vitro.

Q: How does the Ala3 substitution affect the peptide's performance?

The Ala3 substitution increases metabolic resistance, preventing rapid degradation by kinases such as ACE, thereby extending its functional lifespan during biological assays.

Q: What quality certifications accompany this chemical raw material?

Each product is supplied with a Certificate of Analysis (COA), RP-HPLC purity report, and Mass Spectrometry (MS) chromatograms to ensure pharmaceutical-grade quality.

Q: How should Lys-(Ala3)-Bradykinin be stored to maintain its activity?

It must be stored at -20°C in a dry, dark, and well-sealed container. It is critical to avoid repeated freeze-thaw cycles to prevent degradation.

Q: Is this product suitable for clinical use in humans?

No, this product is strictly designated for in vitro laboratory research and preclinical pharmacological studies. It is not for clinical therapeutic use.

Q: What are the available shipping methods for global delivery?

We utilize professional international air freight via DHL, FedEx, UPS, and TNT to ensure rapid transit and minimize environmental impact on the peptide's stability.